1Chavhan A. Sarin, 2Gupta N. Hrishikesh, 3Shinde A. Sushil kumar , 4Phandade V. Govind

DOI : http://dx.doi.org/10.18535/ijahm/v7i4.18

Govt. College of Pharmacy, Kathora Naka Road, Amravati-444604, Maharashtra, India

ABSTRACT:

Herbal remedies are more acceptable in the view that they are safe with fewer side effects than the synthetic ones. Herbal formulations have more demanded in the market. Inflammatory diseases including different types of rheumatic diseases are major cause of morbidity of the working force throughout the world. This has been called the ‘King of human miseries’.  The present work deals with the Development and Evaluation of  Poly-Herbal Anti-inflammatory Formulation containing alcoholic extract of Vitex negundo leaves, Boswellia serrata, Berberis aristata & wintergreen oil. The gel was prepared using polymer carbopol 940 (1% w/v), propylene glycol 400, triethanolamine, propyl paraben, methyl paraben and required amount of distilled water. Various conc. of extract were taken for formulations (F1 to F3). Prepared formulations (F1 to F3) were evaluated for various parameters like colour, appearance, consistency, viscocity, pH, spreadability, stability along with anti-inflammatory activity by using model carageenan induce paw edema in rats. F3 formulation was found optimum for all the parameter.

Key words:  Vitex negundo, Boswellia serrata, spreadability, pH, carbopol.

Reference:

1. Diandian shen, Development of anti-inflammatory agents from the aromatic plants, Origanum spp. and Mentha spp., and analytical methods on the quality control of bioactive phenolic compounds, dissertation work, October, 2008; 2-3.

2.    Abu Syed Md. Mosaddek, Md. Mamun Ur Rashid. Bangladesh J Pharmacology 2008; 3: 44 - 47.

3.    http://www.ayurvedaconsultants.com/herb consult.aspx?commonName=NIRGUNDI accessed on Nov 2010. 

4.    Sultana a., rahman k.u., padmaja a. R. And rahman s., Boswellia serrata roxb. A traditional herb with versatile pharmacological activity: a review , 2013; ijpsr, vol. 4(6): 2106-2117.

5.    Garje K.L., Salunkhe  K.S., Review on: anti-inflammatory herbal gel of Boswellia serrata & Vitex negundo , 2013;  IJPBS  3(2) : 41-49.

6.     Singh A., Duggal S., Kaur N., Singh J., Berberine: Alkaloid with wide spectrum of pharmacological activities, 2010; Journal of Natural Products, 3: 64-75.

7.      Gupta K., Sharma S., Khokra S., Sahu R., Jangde R., Evaluation of wound healing activity of crude extract of Vitex negudo on rats,  Pharmacologyonline, 2012; 2: 1212-1216.

8.      Khadabadi S.S., Deore S.L., Baviskar B.A., “Experimental phytopharmacognosy, A Comprehensive Guide. Nirali Prakashan, first edition, 2011: 5.6-5.7.

9.  Pudke Vrushali k., Development and evaluation of antifungal herbal formulation for subcutaneous infection, dissertation submitted to Sant Gadge Baba Amravati university, Government college of Pharmacy Amravati, 2014; 75-82.

10. Gupta M, Verma PRP, Marwaha RK, Faruk A, Singh G. Formulation and evalution of meloxicam gel. J.Pharm.research 2008;7:27‐31.

11. Jadhav KR, Shetye SL, Kadam VJ. Design and Evaluation of Microemulsion Based Drug DeliverySystem. International Journal of Advances in Pharmaceutical Sciences 2010; 1:156‐166.

12.  Wood JH, Catacalos G, Liberman SV. Adaptation of commercial viscometers for special applications in pharmaceutical rheology ‐ Severs extrusion rheometer. J Pharm Sci 1963; 52:375‐378.

13.  Singh Manish, Formulation and Evaluation of Herbal Gel containing Ethanolic Extract of Ipomoea Fistulosa, IJSR, July 2014; 3(7): 2319-7064.

14.  ICH guidelines. Stability testing of new drug substances and products, Current step 4 version dated 6 February 2003.

15.  (http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q1A_R2/Step4/

       Q1A_R2__Guideline.pdf)