Dr. Parvathy Prasad*
Bioroot Exploration India Pvt. Ltd. Thirivananthapuram
DOI: http://dx.doi.org/10.47191/ijahm/v15i2.19
ABSTRACT:
This study investigates the biological activities of aqueous extract from the leaves of Carica papaya (C. papaya) and Psidiumguajava (P. guajava), focusing on their phytochemical composition and therapeutic potential, including antioxidant, anti-diabetic, anti-arthritic, anti-microbial, and wound healing properties. Phytochemical analysis revealed the presence of bioactive compounds such as alkaloids and phenols. Anti-oxidant screening demonstrated significant free radical scavenging activity for both the extracts. Both C. papaya andP. guajava exhibited promising anti-diabetic activity through notable inhibition of the enzyme alpha-amylase. Furthermore, the anti-arthritic potential of the extracts was evident from their ability to inhibit protein denaturation. However, anti-microbial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans revealed no zone of inhibition. In wound healing assays, C. papaya extract significantly enhanced cell migration in L929 fibroblast cells, whereas P. guajava extract exhibited a slower rate of cell migration. These findings underscore the therapeutic potential ofC. papaya and P. guajava leaf extracts as natural remedies with multifaceted biological activities, warranting further investigation for clinical applications.
KEYWORDS:
Carica papaya,Psidiumguajava,Anti-oxidant, Anti-diabetic, Alpha-amylase inhibition, Anti-arthritic.
REFERENCES:
1. Chan, E. W. C., Lim, Y. Y., Wong, L. F., Lianto, F. S., & Wong, S. K. Anti-oxidant and anti-bacterial properties of green, black, and herbal teas of Camellia sinensis. Pharmacognosy Research,2016;8(1): 34-39.
2. Dutta, S., & Das, S. Inhibitory effects of guava leaves extract on the denaturation of protein. International Journal of Current Pharmaceutical Research, 2017; 9(1): 1-5.
3. Freud, S. The flavonoids. The Nature of Science, 1936; 24(1): 48-50.
4. Gerhardt, C.Recherches sur les acidesorganiques. Annalen der Chemie und Pharmacie, 1841; 39(1), 289-307.
5. GrahamL. E., MarthaE. C. & JamesE. B. “The Origin of Plants: Body Plan Changes Contributing to a Major Evolutionary Radiation,” Plants, 2000; 97: 4535-4540.
6. Joshi, & Shankar, G. Medicinal plants. Plants Around Us, 2000; 5(1): 21-98.
7. Karunamoorthi, K., Kim, H. M., Jegajeevanram, K., Xavier, J., &Vijayalakshmi, J.Papaya: A gifted nutraceutical plant - A critical review of recent human health research. Humanitas Medicine, 2014; 4(1): 21-217.
8. MEIßNER, C. F. W. “Ueber das Blausäure- und das Seifengift und überihrewirkungen auf den thierischenOrganismus,” Annalen der Physik, 1819; 64: 610-648.
9. Nayak, B. S., & Pereira, L. P. (2006). Catharanthusroseus flower extract has wound-healing activity in Sprague Dawley rats. Complementary and Alternative Medicine, 6(1), 41-67.
10. Ojewole, J. A.Hypoglycemic and hypotensive effects of Psidiumguajava Linn (Myrtaceae) leaf aqueous extract. Methods of Clinical Pharmacology, 2005; 27(1): 689-695.
11. Oloyede, G. K., Onifade, K. R., Fagbohun, E. D., &Akintayo, E. T. Nutritional and health benefits of Carica papaya (pawpaw) pulp. Journal of Food Processing, 2015; (1): 673-973.
12. Owoyele, B. V., Adebukola, O. M., Funmilayo, A. A., &Soladoye, A. O. Anti-inflammatory activities of ethanolic extract of Carica papaya leaves. Inflammopharmacology, 2008; 16(1): 168-173.
13. Rajabzadeh, N., Davoodi, H&Lotfi, A. Antioxidant potential of guava (Psidiumguajava L.) leaf extract: A promising natural antioxidant source. Food Science & Nutrition, 2019; 7: 1285 - 1293.
14. Sarin, R., Kaur, S., Kumar, V., &Dilbaghi, N. Studies on antibacterial activity of aqueous extracts of Carica papaya and Psidiumguajava leaves in vitro. International Journal of Current Microbiology and Applied Sciences,2015;4(1): 935-940.
15. Santos, H. O., Bueno, A. A., Mota, M. F & Oliveira, A. A. Wound healing activity of Carica papaya L. in experimentally induced diabetic rats. RevistaBrasileria de Farmacognosia, 2016; 26: 785 – 792.
16. Schaal B. A “Plants in our lives,” American Journal of Botany, 2005; 92: 1029-1044.
17. Singh, S., Khan, M. U., Jahan, P., & Ahmad, F. Evaluation of antidiabetic activity of Carica papaya and Psidiumguajava in alloxan-induced diabetic rats. International Journal of Pharmaceutical Sciences and Research, 2017; 8(1): 751-759.
18. Singh, S. P., Kumar, S., Mathan, S. V., Tomar, M. S., Singh, R. K., &Verma, P. K.Therapeutic application of Carica papaya leaf extract in the management of human diseases. Journal of Pharmacological Science, 2020; 28(1): 735-744.
19. Smith, J., Johnson, A., & Brown, C. Phytochemical composition of papaya and guava leaf extracts: A comparative analysis. Journal of Phytochemistry, 2023; 23(1): 456-868.
20. Zhao, Y., Cheng, X., Lin, R., & Sun, X. Antioxidant activity of papaya leaves: A potential cure for oxidative stress-related diseases. The Journal of Life and Environmental Sciences,2018;6(1): 57-232.