Development and Evaluation of Anti-Inflammatory Activity of Hibiscus Emulgel

Published: Saturday, 13 September 2014 10:43 | Written by Super User | Print | Email | Hits: 4616

B. Mounika¹, I. Bala Tripura Sundari².

DOI : http://dx.doi.org/10.31142/ijahm/v9i2.03

¹M Pharmacy, Sri Venkateshwara College of Pharmacy, Osmania University, Hyderabad-81.

²Assistant Professor, Sri Venkateshwara College of Pharmacy, Hyderabad-81.

Corresponding Author: B. Mounika

Sri Venkateshwara College of Pharmacy, Madhapur, Hyderabad-81.

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ABSTRACT:

Objective: To formulate and evaluate anti-inflammatory activity of Hibiscus emulgel.

Methods: The emulsions of methanolic extract of Hibiscus were prepared by using different oils like light liquid paraffin, coconut oil, olive oil and by using varying concentrations of Tween80 and Span80. Based on the physicochemical characteristics the best selected emulsion was formulated into emulgel by using different gelling agents like Carbopol 934,HPMC E15, NaCMC in different ratios. Optimization of the prepared emulgel formulations was done based on for their physicochemical parameters and percentage drug release. Optimized formulation OEG4 was evaluated for Anti-inflammatory activity using carrageenan-induced rat paw oedema model.

Results: The present investigation shows the physicochemical characterization of prepared emulgels such as spread ability, viscosity, drug content, In vitro diffusion studies, stability studies. The stability studies were performed as per ICH guidelines at two different temperatures for 3months i.e., room temperature (25±2⁰C/60+5%RH) and (40±2̊C/75+5%RH). The drug content of the optimized formulation OEG4 was monitored for a period of 90days. The optimized emulgel formulation OEG4 was compared with Diclofenac sodium as a standard drug for evaluating theanti-inflammatory activity. The optimized formulation showed maximum inhibition of 85.46% was observed at 4hrs of administration. There was statistically significant reduction in paw edema by test gel (p<0. 01) when compared with standard emulgel.

Conclusion: The present study concluded that Hibiscus emulgel showed potential anti-inflammatory activity.

Key Words: Carbopol934, HPMC E15, HPMC K4M, NaCMC, Hibiscus, Emulgel.

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Development and Evaluation of Anti-Inflammatory Activity of Hibiscus Emulgel

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