Experimental Study on Albino Rats To Evaluate The Anti-Anxiety Effect of Kushmanda Beej Choorna

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¹Bharti ,²Sharma Subhash , ³Toor Raman , ⁴Sharma Manisha

DOI : http://dx.doi.org/10.31142/ijahm/v8i.4.04

¹M.D. Ayu, Reader, Deptt. Of Kayachikitsa, G.N.A.M.C.,Gopalpur, Ludhiana(Pb.)

²M.D. Ayu, Lecturer, Deptt. Of Panchkarma, G.N.A.M.C.,Gopalpur, Ludhiana(Pb.)

³M.D. Ayu, Lecturer, Deptt. Of Agad Tantra, G.N.A.M.C.,Gopalpur, Ludhiana(Pb.)

⁴M.D. Ayu, Reader, Deptt. Of Rog Nidan, G.N.A.M.C., Gopalpur, Ludhiana(Pb.)

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Abstact:-

Introduction: Anxiety Disorder is a Manasika Vikara mentioned in Ayurvedic literature which is a gift of today’s stresseful lifestyle. In Ayurvedic classics, Medhya drugs like Kushmanda are indicated to improve functions of Manas and Buddhi.

Aims and Objectives: The study was planned on albino rats to evaluate the anti anxiety effect of Kushmanda beeja Choorna.

Materials and Methods: Kushmanda Beej Choorna was administered to 20 rats divided into 2 groups containing 10 rats in each group. From day 1 to day 5, two groups were administered through intra gastric tube using 2 ml disposable syringe fitted with 18 gauze needle, with the estimated dose of distilled water and trial drug i.e. Beeja Choorna of Kushmanda respectively. On 6thday, one hour after the respective drug administration, effect was observed on the basis of animal model Elevated plus maze and few parameters were recorded.

Result: Dunnett’s post hoc test and student unpaired‘t’ test were applied to trial group in comparison with control group showed statistically highly significant result with p value < 0.001 in the number of entries to the open arm, statistically significant result with p 0.002 on the latency of first entry to the closed arm and moderately statistically significant with p 0.012 in time spent in open arms.

Conclusion: It was concluded that the trial formulation contains good anti anxiety properties so can be used in the management without any side effects.

Keywords: Anxiety, Ayurveda, Kushmanda

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