Dandge P.B¹*,  Kulkarni A. S², Nadaf S. H³, Dandge P.B⁴, Shinge A. J⁵,  Rajguru S. V⁶

^1,2,3Department of Biochemistry, Shivaji University, Vidyanagar, Kolhapur (MS) India

⁴Department of Chemistry, Shivaji University, Vidyanagar,Kolhpur (MS) India.

                                                           ^5,6Department of Statistics, Shivaji University, Vidyanagar,Kolhpur (MS) India                                                                                                                            

Abstract:Herbal plants have long been used in traditional medicine to address and heal a wide range of health-related issues. Withania coagulans (Family; Solanaceae), a valuable medicinal plant used to evaluates bioactives by using maceration. Phytochemical analysis evaluated by qualitatively for five different extract. Methanol extract has highest phytocostitutents so further used for analysis phenolic compounds (86.67 ± 3.19 mg GAE/g) and flavonoids (60.95 ± 2.70 mg QE/g). The methanol extract demonstrated significant antioxidant activity in the DPPH and FRAP assay with IC₅₀ value 63.02±1.08 μg/ml and 70.2±1.11 μg/ml respectively and notable antibacterial activity against Escherichia coli and Staphylococcus aureus. Additionally, the methanol extract exhibited substantial anti-diabetic potential, with IC₅₀ value 602.6±2.98 μg/ml. This study demonstrated that the methanolic extract of Withania coagulans is a potent natural antioxidant, which could be beneficial in slowing the progression of various oxidative stress-related conditions.

KEYWORDS: Withania coagulans, antioxidant, anti-diabetic

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Dr. Sabarinath M K

Assistant Professor, Dept. of Shalakya tantra, SDM College of Ayurveda, Hospital and Research Centre Udupi.

ABSTRACT:

Introduction: Indralupta is one among the shiro kapalagata roga. According to Acharya Vagbhatta, pitta along with vata invades the romakoopa causes hairfall. Vitiation of Sleshma along with shonita obstructs the channels of Romakoopa leading to the stoppage of regrowth of hair¹. This condition is known as Indralupta. Indralupta can be correlated with Alopecia areata in which there is a sudden hairfall that strarts with one or more circular bald patches. In Ayurveda both shodhana and shamana treatments are prescribed for Indralupta. This is a case report of 25 year old male patient complaints of patchy hair loss and thinning of hair since 2 months.

Materials and Methods: The subject who approached Shalakya tantra opd of SDM Ayurveda hospital Udupi with symptoms of patchy hair loss and thinning of hair since 2 months was systematically reviewed and treatment modalities like pracchana and internally Arogyavardhini rasa, Tiktaka kashaya, Saptamruta loha and Bhargava prokta rasayana is advised.

Results: The subject showed marked improvement symptomatically.

Discussion: Ayurveda has great approach in curing the Indralupta. Nidana parivarjana, shamanoushadis and external applications are the main treatment modalities which can be concluded from this case report.

KEYWORD :Indralupta, Alopecia areata, Pracchana

REFERENCES:

1. Acharya vagbhatta: Ashtanga hrudaya text with English translation by prof. K.R Srikantha murthy. Varanasi: choukhamba krishnadas academy: reprint edition 2006. Uttara tantra, chapter 23, shloka 24-25, page 222.
2. Agnivesha: Charaka samhita with Ayurveda deepika commentary edited by Vaidya Jadavaji Trikamji Acharya, Varanasi: choukhambha prakashan: reprint edition 2009. Chikitsa sthana,chapter 15, shloka 96-97, page 520.
3. Acharya vagbhatta: Ashtanga hrudaya text with English translation by prof. K.R Srikantha murthy. Varanasi: choukhamba krishnadas academy: reprint edition 2006. Uttara tantra, chapter 24, shloka 24, page 228.
4. Acharya vagbhatta: Ashtanga hrudaya text with English translation by prof. K.R Srikantha murthy. Varanasi: choukhamba krishnadas academy: reprint edition 2006. Uttara tantra, chapter 39, shloka 169-173, page 410.
5. Agnivesha: Charaka samhita with Ayurveda deepika commentary edited by Vaidya Jadavaji Trikamji Acharya, Varanasi: choukhambha prakashan: reprint edition 2009. Chikitsa sthana,chapter 15, shloka 19, page 515.