Dr. Ch. Srinivasa Prasadacharyulu

DOI : http://dx.doi.org/10.31142/ijahm/v9i3.03

Associate Professor of Biochemistry P.V.K.N.Govt.College, Chittoor Andhra Pradesh, India

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ABSTRACT

Azadiracta indica (Neem)  native of India has uncountable medicinal properties of variousbioactive compounds which are present in the roots to seeds of this plant.Biologically active compounds namely Azadirachtin, meliacin, , Meliantriol ,Nimbin, Nimbidin, Salannin, Salannol vilasinin,are isolated from different parts of Neem plant .Biologically more active compound is azadirachtin, a tetranotriterpenoid is isolated from the seeds of Neem which is actually a mixture of seven isomeric compounds named as azadirachtin A-G and azadirachtin E is the most effective one. Two bioactive compounds  azadirachtin M and azadirachtin N collected from seed kernels of  Azadirachta indica,these two compounds hasa major role in medicinal activities.The bioactive compound “Azadiachtin” has antimalarial, antigingivitis and antiplaque properties and also has antibacterial action by destroying the bacterial cells.The bioactive compound Nimbidin has anti- inflammatory antipyretic , antiarthritic , hypoglycemic , anti- gastric ulcer, antibacterial  and antifungalproperties.Nimbin exhibits spermicidal function. The neem oil was extracted from neem kernels. This oil  used in  soap industry and by pharmaceutical industries and contain many active ingredients which are  called triterpene or limonoids .Neem oil showed good antiseptic properties. It is applied in the treatment of  skin complaints as furuncles and eczema.Therapeutical potentials of neem is due to the presence of various Bioactive compounds in roots to seeds of its body.

Key Words: (1). Azadiracta indica (2). Bioactive compounds (3). Azadiractin,(4). Nimbin, (5). Nimbidin etc., (6). Antimalarial, anti inflammatory and antiarthritic etc

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