Siva Prasad Kanchi

DOI : http://dx.doi.org/10.31142/ijahm/v9i3.06

SVSSC Government Degree College, Shar Road, Sullurpet, Spsr Nellore District, Andhra Pradesh, India

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ABSTRACT

Centella asiatica (gotukola) has been used as a medicine in the Ayurvedic tradition of India for thousands of years.  It is listed in the historic Susruta samhita, an ancient Indian medicinal text. In China, gotukola is one of the reported “Miracle elixirs of life”. In 19th century, Gotukola and its extracts were incorporated into the Indian pharmacopeia and considered as the Food for the brain.  This study evaluated the anticonvulsant    effect   of chloroform   extract   of Centella asiatica   (CA) with  particular   reference   to carbohydrate  metabolism   in different   types  of  rat  muscles.   The rats were randomly divided into 4 groups having 6 in each group:  i.e.  Control  group  received   Saline,  PTZ-induced   epileptic   group  (60  mg/kg  b.w op/ 1 day),  Epileptic  group  pretreated  with  chloroform   extract  (CE),   and    Epileptic  group  pretreated  with  Diazepam  (DP;  Reference  control)  (2 mg/kg  b.w/ip/ day).  The  CA extract  is  administered   at the  dose  of 200  mg/kg  body  weight  orally  for  one week.  The experimental results were observed that the decreased content of Total carbohydrates in the muscles i.e. White Vastus (WV), Red Vastus (RV), Soleus (Sol) and Gastrocnemius (GN); increased the glycogen and glucose levels during PTZ-induced epilepsy in all the muscles.   The   reversal   changes   were   observed   on    pre­ treatment   with the chloroform   extract and diazepam.   Hence, it is evident that the different   bioactive factors   of Centella offered protection against   PTZ-induced   epilepsy.

Keywords:      Epilepsy, Anticonvulsant,    Centella   asiatica,   Pentylenetetrazole, carbohydrate,  rat muscle.

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