¹Sonia Mol Joseph, ²Amala Dev A. R

 DOI : http://dx.doi.org/10.31142/ijahm/v11i3.02

^{1, 2} PG & Research Department of Chemistry, Mar Ivanios College (Autonomous), Thiruvananthapuram, Kerala

Download Pdf 

Abstract:-

This study reports the comparison of chemical composition and antioxidant activity of leaf essential oil from two Annona species - Annona glabra and Annona reticulata by GC-MS method. Out of the forty-one compounds identified from essential oil analysis comprising 80.5% to 96.1% from A. reticulata and A. glabra. In A. glabra leaf oil, 27 compounds were identified whereas in A. reticulata leaf oil, 30 compounds were identified. Essential oil of A. glabra was dominated by diterpenoids whereas that of A. reticulata by sesquiterpenoids. E-nerolidol (26.9%) and spathulenol (16.7%) were the major constituents of A. glabra. But in A. reticulata, β-elemene (17.8%) and E-phytol (15.3%) were identified at higher concentrations. Diterpenoids (76.3%) and sesquiterpene hydrocarbons (43.7%) were the major class of compounds in A. glabra and A. reticulata respectively. Elemol (8.7%), β-Pinene (7.4%), α-Pinene (6.9%) and β-Elemene (5.3%) were some of the main compositions of A. glabra leaves whereas β-Caryophyllene (7.9%), α-Pinene (7.7%), Spathulenol (5.5%) and β-Pinene (5.1%) were the major constituents in A. reticulata leaves. Antioxidant activity was not detected by the DPPH assay for both the oils evaluated. Results of the GC-MS analysis supported the fact that these essential oils may become useful in the research of new therapeutic agents of promising clinical use.

Keywords: Essential oil , Annona species, Diterpenoids, Sesquiterpenoids, Therapeutic agents

REFERENCE:

1. Baskar R, Rajeswari V, Kumar TS. In vitro antioxidant studies in leaves of Annona species. Indian J Exp Biol 2007; 45:480.
2. Shital SC, Prashant BS, Manoj GD, Deepak PP. A comprehensive review on Annona reticulata. Int J Pharm Sci Res 2014; 5:45-48.
3. Gilbert F, Michel LA. Annonaceae essential oil: A review. J Essent Oil Res 1999; 11:131-136.
4. Jamkhande PG, Wattamwar Annona reticulata Linn. (Bullock's heart): Plant profile, phytochemistry and pharmacological properties. J. Tradit Complement Med 2015; 5:144-148.
5. SureshHM, Shivakumar B, Hemalatha K, HeroorS, Hugar DS, Rao KRS, et al. In vitro Antiproliferative activity of Annona reticulata roots on human cancer cell lines. J Pharmacog Res 2011; 3:9 -16.
6. Shivanna LM, Urooj A. Apoptotic Effects of Annona reticulata leaves Extract in HT-29 Cell Lines. Asian J Biol Sci 2019; 12:820-825.
7. Thang TD, Kuo PC, Huang GJ, Hung NH, Huang BW, Yang ML, et al. Chemical constituents from the Leaves of Annona reticulata and their inhibitory effects on NO Production. Molecules 2013; 18:4477-4482.
8. LiuY, Liu D, Wan W, Zhang In vitro mitochondria-mediated anticancer and antiproliferative effects of Annona glabra leaf extract against human leukemia cells. Photochem Photobiol B 2018; 189:29-32.
9. Elhawary SS, Tantawy MEE, Rabeh MA, Fawaz NE. DNA fingerprinting, chemical composition, antitumor and antimicrobial activities of the essential oils and extractives of four Annona species from Egypt. J Nat Sci Res 2013; 3:59-65.
10. Zhang Y, Peng H, Xia G, Wang M. Anticancer effect of two diterpenoid compounds isolated from Annona glabra Linn. Acta Pharmacol Sin 2004; 25:937-943.
11. Liu XX, Alali FQ, Pilarinou E, McLaughlinb JL. Two bioactive mono-tetrahydrofuran acetogenins, annoglacins A and B, from Annona glabra. Phytochemistry 1999; 50:815-819.
12. Padmaja V, Hara N, Fujimoto Y, Hisham Biological activities of Annona glabra. J Ethnopharmacol 1995; 48:21-26.
13. Thang TD, Dai DN, Hoi TM, Ogunwande IA. Study on the volatile oil contents of Annona glabra L., Annona squamosa L., Annona muricata L. and Annona reticulata L., from Vietnam. Nat Prod Res 2013; 27:1232-1237.
14. Isiaka AO, Olusegun E, Nureni OO, Adeleke AK. Essential oil of Annona reticulata L. leaves from Nigeria. J Essent Oil Res 2006; 374-378.
15. Tepe B, Daferera D, Sokmen A, Sokmen M, Polissiou M, et al. Antimicrobial and antioxidant activities of the essential oil and various extracts of Salvia tomentosa Miller (Lamiaceae). Food Chem 2005; 90:333–340.
16. Identification of Essential Oil Components by Gas Chromatography/Mass spectroscopy, 4th Edition. R. P. Allured Publishing Co, Carol Stream, Illinois, 2007.
17. Xie Q, Li F, Lie F, Liu W, Gu C. Bio Med Res Int 2020; 2:1-10.
18. Chan WK, Tan LT, Chan KG, Lee LH, Goh BH, et al. A sesquiterpene alcohol with multi-faceted pharmacological and biological activities. Molecules 2016; 6:21-31.