^Back To Top

foto1 foto2 foto3 foto4 foto5


IJAHM Latest Issue IJAHM have published its latest issue Vol. 14 Issue 06, Nov.-Dec. 2024 published IJAHM Call For Paper invites paper from various Ayurveda & herbal Medicine for Volume 14 Issue 06 Nov.-Dec..-2024 ...... Impact Factor : 8.003

Dr.  Bhatt Narendra1,    Dr. Deshpande Manasi2

 DOI : http://dx.doi.org/10.47191/ijahm/v11i6.02

 1Consultant- Ayurveda, Research & Industry, CRIA Consultants Pvt. Ltd. 15, Bachubai Building, J.Bhatankar Marg, Parel, Mumbai 400 012,

 2Professor and Head, Department of Dravyaguna Vigynan, Bharati Vidyapeeth [Deemed to be University], College of Ayurved, Pune, 411043

Download Pdf 

ABSTRACT:

Liver disorders mostly represent a prolonged dysfunction associated with different routes of cellular and biological alterations due to variety of reasons. Present treatments are found to be of limited use. Indigenous systems of medicine Ayurved, Siddha and Unani are extensively used to provide relief in variety of liver diseases. The understanding of liver functions, its dysfunctions and treatments offered have been of research interests. A series of review papers have been published by the authors covering different aspects including classical, proprietary and This review paper- part II is the outcome of the systematic effort and analyses of hepatoprotective formulations and ingredients with the updated information on phytochemical and pharmacological- safety aspects. This strongly emphasizes on the role of ASU products and ingredients to treat chronic or severe liver diseases. These systems and scientific information on products and plants exhibit huge translational potentials to evolve new path to understand and develop new safe and effective therapeutic approaches and drugs to treat liver disorders.

Key words: Liver disorders, Ayurved, Siddha, Unani, Medicinal plants, pharmacology

REFERENCES:

  1. Mukherjee, P. S., Vishnubhatla, S., Amarapurkar, D. N., Das, K., Sood, A., Chawla, Y. K., Eapen, C. E., Boddu, P., Thomas, V., Varshney, S., Hidangmayum, D. S., Bhaumik, P., Thakur, B., Acharya, S. K., & Chowdhury, A. (2017). Etiology and mode of presentation of chronic liver diseases in India: A multi centric study. PloS one12(10), e0187033. https://doi.org/10.1371/journal.pone.0187033
  2. Bhatt AD, Bhatt NS. Indigenous drugs and liver disease. Indian J Gastroenterol.1996; 15: 63-67
  3. Valvi AR, Mouriya N, Athawale RB, Bhatt NS. Hepatoprotective Ayurvedic plants - a review. J Complement Integr Med. 2016 Sep 1;13(3):207-215. doi: 10.1515/jcim-2015-0110. PMID: 27310002.
  4. Bhatt N. & Deshpande M. (2018). Int J Ayu Pharm Chem Liver Disorders and Potential Medicinal plants: A Review Study. 2018; 9 (10).10.13140/RG.2.2.15990.45120
  5. Bhatt N, Deshpande M, Namewar P and Pawar S: A review of classical, proprietary and patented Ayurved products and their ingredients in liver/sleen diseases. Int J Pharm Sci & Res.2018; 910: 4056-70. doi: 10.13040/IJPSR.0975-8232.910.4056-70
  6. Narendra Bhatt, Dr. Sudha Revathy, Dr. Manasi Deshpande A Review of Siddha Traditional System Products and Their Ingredients in Liver Diseases, International Journal of AYUSH; 2020: 9 (2);55-74
  7. Shaikh ZA, Kamyab SS, Deshpande MM, Mulla GJ, Bhatt NS and Moghe AS: A systematic review of Unani formulations for potential in treatment of hepatocellular carcinoma. Int J Pharm Sci & Res 2021; 12(10): 5253-63. doi: 10.13040/IJPSR.0975-8232.12(10).5253-63
  8. AFI: Ayurvedic Formulary Of India, Vol I-III, 1st Edition Delhi (IN): Government Of India, Ministry Of Health And Family Welfare, Department Of Ayurveda, Yoga & Naturopathy, Unani, Siddha And Homoeopathy.2000, 2003, 2011
  9. SFI, Siddha Formulary of India, 1st Edition Delhi (IN): Government Of India, Ministry Of Health And Family Welfare, Department of Indian Systems Of Medicine & Homoeopathy. 1992
  10. UFI: The Unani Pharmacopoeia of India, Part II (Formulations) , Vol I-IV, 1st Edition Delhi (IN): Government Of India, Ministry of Health And Family Welfare, Department Of Ayurveda, Yoga & Naturopathy, Unani, Siddha And Homoeopathy.2009,2010,2016,2019
  11. NFUM: National Formulary of Unani Medicine, Part I-VI, 1st edition Delhi (IN): Government of India, Ministry of Health and Family Welfare, Department of Indian Systems of Medicine & Homoeopathy. 1984,1994, 2001, 2006, 2008, 2011
  12. API: The Ayurvedic Pharmacopoeia of India, 1st Edition, Part I, Delhi (IN): Government of India, Ministry of Health And Family Welfare, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy.1986, 1999, 2001, 2004; Volume I-VI. doi:10.5455/JREIM.82-142002664006
  13. API:: The Ayurvedic Pharmacopoeia of India, 1st Edition Part II (Formulations) Delhi (IN): Government of India, Ministry of Health and Family Welfare, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy. 2007,2008,2010,2017; Vol- I-IV
  14. SPI: Siddha Pharmacopoeia of India, Part I, 1st Edition Delhi (IN): Government of India, Ministry of Health And Family Welfare, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy. 2008,2011; Vol I-II,
  15. UPI: The Unani Pharmacopoeia of India Part-I. 1st Edition Delhi (IN): Government of India, Ministry of Health And Family Welfare, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha and Homoeopathy. 2007, 2008, 2009; Vol I-IV
  16. Essential drug list [EDL], Ayurved, Delhi (IN): Government of India Department of AYUSH, Drug control cell, Ministry of Health and Family Welfare, Department of AYUSH;
  17. Essential drug list [EDL], Unani Medicine, Delhi (IN): Government of India Department of AYUSH, Drug control cell, Ministry of Health and Family Welfare, Department of AYUSH;
  18. Essential drug list [EDL], Siddha Medicine, Delhi (IN): Government of India Department of AYUSH, Drug control cell, Ministry of Health and Family Welfare, Department of AYUSH;
  19. Perspectives of Indian Medicinal Plants in the Management of Liver Disorders, Indian Council of Medical Research; 2008 edition (April 1, 2008)
  20. Sangeeta Rongson, Niten Barman. A Conceptual Study of Raktavaha Srotas and its Disease. International Journal of Ayurveda and Pharma Research.2017; 5(6):89-95.
  21. Panda AK, Bhuyan GC, Rao MM. Ayurvedic Intervention for Hepatobiliary Disorders: Current Scenario and Future Prospect. J Tradit Med ClinNatur. 2017; 6:210.
  22. Kashinath Pandey, Dr. Gorakhnath Chaturvedi, edited by Pt. Rajeshwardutt Shashtri, Charak Samhita- SavimarshVidyotini Hindivyakhyopeta, Chaukhambha Bharati Academy, Varanasi, Reprint 2008, Vimansthan, chapter 5, verse 7, page 711
  23. Sushruta, Sushrut Samhita, with commentary of Dalhana, Edited by Vaidya Jadavaji Trikamji, Chaukhambha Orientalia, Varanasi, 8th Edition, 2005, Sutrasthana, Chapter 14, verse 4,page 59
  24. Lad, Vasant, M.A.Sc., Textbook of Ayurveda Fundamental Principles. 2002; p. 57-58
  25. Mohamed S. Al-Shinnawy, Ahmed R. Hassan, Dalia A. Ismail and Mohamed A. Shahin The Potential Protective and Therapeutic Effects of Aloe Vera Juice on Malathion Induced Hepatotoxicity in Rabbits The Egyptian Journal of Hospital Medicine. April 2014; Vol. 55, Page 146–158
  26. H, Tiwari P, Srivastava M, Ghoshal S. Hepatoprotective and Histopathological Activity of Ethanol and Aqueous Extracts of Stem of Aloe Vera Linn (Ghee Gangwar) Against Paracetamol-induced Liver Damage in Rats. International Journal of Pharmacy & Bio-Sciences. 2016 Jan 8
  27. Chandan BKSaxena AKShukla SSharma NGupta DKSuri KASuri JBhadauria MSingh B.Hepatoprotective potential of Aloe barbadensis Mill.against carbon tetrachloride induced hepatotoxicity.J Ethnopharmacol.2007 May; 22; 111(3):560-6. Epub 2007 Jan 14.
  28. Cui, Yan & Ye, Qing & Wang, Heya & Li, Yingchao & Yao, Weirong & Qian, He. Hepatoprotective Potential of Aloe vera Polysaccharides against Chronic Alcohol-induced Hepatotoxicity in Mice. Journal of the science of food and agriculture. 2014; 94. 10.1002/jsfa.6489
  29. Guo X, Mei N. Aloe vera: A review of toxicity and adverse clinical effects. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2016; 34(2):77–96. doi:10.1080/10590501.2016.1166826
  30. Patel, Krishna & Gupta, Gajendra & Goyal, Dr. Manoj & Nagori, Badri. Assessment of hepatoprotective effect of Tecomella undulata on paracetamol-induced hepatotoxicity in rats. Revista Brasileira de Farmacognosia.Feb 2011; 21 (1) . https://doi.org/10.1590/S0102-695X2011005000020 
  31. D Singh, RS Gupta. Hepatoprotective Activity of Methanol Extract of Tecomella undulata against Alcohol and Paracetamol Induced Hepatotoxicity in Rats. Life Sciences and Medicine Research, Volume 2011: LSMR-26
  32. K. Gole, S. Dasgupta, R. K. Sur & J. Ghosal (1997) HEPATOPROTECTIVE EFFECT OF AMOORA ROHITUKA, International Journal of Pharmacognosy, 35:5, 318-322,
  33. Handa SS, Sharma A., Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. Indian J Med Res 1990, 92, 276-278
  34. Visen pks, Shukla B, Patnail GK, Dhawan BN, Angrapholide protects rat hepatocytes against paracetamol induced damage. J Ethnopharmacol 1993, 40, 131-136
  35. C. Rana and Y. Avadhoot, Hepatoprotective effects of Andrograhphis paniculata against carbon tetrachloride-induced liver damage,” Archives of Pharmacal Research, vol. 14, no. 1, pp. 93–95, 1991
  36. R. Choudhury and M. K. Poddar, “Andrographolide and kalmegh (Andrographis paniculata) extract: in vivo and in vitro effect on hepatic lipid peroxidation,” Methods and Findings in Experimental and Clinical Pharmacology, vol. 6, no. 9, pp. 481–485, 1984.
  37. Choleretic action of andrographolide obtained from Andrographis paniculata in rats, Phytotherapy research,1991,  Volume5, Issue4, 176-178
  38. Handa SS, Sharma A., Hepatoprotective activity of andrographolide against galactosamine & Paracetamol intoxication in rats. Indian J Med Res 1990, 92, 284-92
  39. Dhawan BN Effect of Andraphlide against galactosamine induced hepatotoxic.Fitoterapia 1995,66 415-420 S. Tripathi, Y. B. Tripathi
  40. R. Choudhury, S. J. Haque, and M. K. Poddar, In vivo and in vitro effects of kalmegh (Andrographis paniculata) extract and andrographolide on hepatic microsomal drug metabolizing enzymes. Planta Medica. 1987; vol. 53, no. 2, pp. 135–140
  41. Kapil A, Koul IB, Banerjee SK, Gupta BD. Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata, Biochem Pharmacol, 1993, 46 182-185
  42. Dutta A, Sukul NC.Filaricidal properties of a wild herb, Andrographis paniculata. J.Helminthol 1982, 56 81-84
  43. Pingale Shirish S, hepatoprotection study of leaves powder of Azadirachta indica a. Juss. International Journal of Pharmaceutical Sciences Review and Research. July – August 2010 ; Volume 3, Issue 2, Article 007
  44. Kale B. P., Kothekar M. A., Tayade H. P., Jaju J. B., Mateenuddin M. Effect of aqueous extract of Azadirachta indica leaves on hepatotoxicity induced by antitubercular drugs in rats. Indian Journal of Pharmacology. 2003;35:177–180.
  45. Shivashankaramurthy, K.G. & Kiran, L.J. Evaluation of hepatoprotective activity of aqueous extract of Azadirachta indica (Neem) leaves against paracetamol induced hepatotoxicity in albino rats. Pharmacologyonline. 2011; 1013-1024.
  46. Bhanwra S. Effect of Azadirachta indica (neem) leaf aqueous extract on paracetamol induced liver damage in rats. Indian Journal of Physiology and Pharmacology. 2000;44(1):64–68.
  47. Devmurari V. P., Jivani N. P. Hepatoprotective activity of methanolic and aqueous extracts of Azadirchata indicaInternational Journal of  Pharm Tech  Research. 2010; 2(2):1037–1040. 
  48. Kalaivani T., Meiganam E., Premkumpatoprotectivear N., Siva R. Studies on hepatoprotective properties of leaf extracts of Azadirachta indica Juss (Meliaceae) Ethnobotanical Leaflets. 2009; 13(2):165–170. 
  49. Mohamed A. Dkhil,Saleh Al-Quraishy,  Ahmed M. Aref, Mohamed S. Othman,  Kamal M. El-Deib,   Ahmed E. Abdel Moneim,  The Potential Role of Azadirachta indica Treatment on Cisplatin-Induced Hepatotoxicity and Oxidative Stress in Female Rats, 2013; Oxid Med Cell Longev.
  50. Baligar N. S., Aladakatti R. H., Ahmed M., Hiremath M. B. Evaluation of acute toxicity of neem active constituent, nimbolide and its hepatoprotective activity against acute dose of carbon tetrachloride treated albino rats, International Journal of Pharmaceutical Sciences and Research. 2014;5(8):3455–3466.
  51. Baligar N. S., Aladakatti R. H., Ahmed M., Hiremath M. B. Hepatoprotective activity of the neem-based constituent azadirachtin-A in carbon tetrachloride intoxicated Wistar rats, Canadian Journal of Physiology and Pharmacology. 2014;92(4):267–277
  52. Shori Amal Bakr. Evaluation of Acute Toxicity of Water Extract of Azadirachta indicaLeaves and Seeds in Rats. Pakistan Journal of Biological Sciences. 2013. 16: 697-700
  53. Glinsukon, T., R. Somjaree, P. Piyachaturawat and Y. Thebtaranonth. Acute toxicity of nimbolide and nimbic acid in mice, rats and hamsters. Toxicol. Lett., 1986; 30: 159-166
  54. Wang C, Cao M, Shi DX, Yin ZQ, Jia RY, Wang KY, Geng Y, Wang Y, Yao XP, Yang ZR, Zhao J. A 90-day subchronic toxicity study of neem oil, a Azadirachta indica oil, in mice. Hum Exp Toxicol. 2013 Sep;32(9):904-13. doi: 10.1177/0960327113475677. Epub 2013 Feb 25. PMID: 23444337.
  55. Gandhi MLal RSankaranarayanan ABanerjee CKSharma PL, Acute toxicity study of the oil from Azadirachta indica seed (neem oil). J Ethnopharmacol.1988 May-Jun; 23(1):39-51.
  56. Ahmad M, Alamgeer, Chaudhary MZ, Nadeem M, Sharif T, Ahmad B. Hepatoprotective effect of Berberis lycium (Royle) in hepatotoxic rabbits. Gomal. Uni. J. Res. 2008; 24:24

Ahmad M, Alamgeer, Chaudhary MZ, Nadeem M, Sharif T, Ahmad B. Induced Acute Hepatotoxicity in Rats. Asian Journal of Pharmaceutical and Clinical Research..  Hepatoprotective effect of Berberis lycium (Royle) in hepatotoxic rabbits. Gomal. Uni. J. Res. 2008; 24:24.

  1. Gilani AH, Janbaz KH. Preventive and curative effects of Berberis aristata fruit extract on paracetamol and CCl4 induced hepatotoxicity. Phytother Res 1995;9:489–494
  2. Dehar, N., R. Walia, R. Verma, and P. Pandey. Hepatoprotective Activity of Berberis aristata Root Extract against Chemical 2013; Vol. 6, no. 9, Nov. pp. 53-56,
  3. Manikyam HK, Ramesh C, Yadav P and Kenttar A: Berberine chloride induced apoptosis in HepG2 cancer cell line viaPPAR gamma activation and COX2 inhibition by regulating prostaglandin E2 (PGE2) signalling pathway. Int J Pharm Sci & Res 2018; 9(11): 4723-28. doi: 10.13040/IJPSR.0975-8232.9(11).4723-28.
  4. Chang, H. Yan, J. Fei et al., Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats. Journal of Lipid Research, vol. 2010; 51, no. 9, pp. 2504–2515.
  5. Nitika Singhand Bechan Sharma, Toxicological Effects of Berberine and Sanguinarine.  Front Mol Biosci. 2018; 5: 21
  6. T. Olaleye, A. C. Akinmoladun, A. A. Ogunboye, and A. A. Akindahunsi, Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusaLinn against acetaminophen-induced liver damage in rats, Food and Chemical Toxicology, vol. 48, no. 8-9, pp. 2200–2205, 2010.
  7. Patel Monali, Verma Ramtej, Hepatoprotective Activity of Boerhavia diffusa Extract, IJPCR, Vol 6, Issue 2, July-September 2014, 233-240
  8. Venkatalakshmi, V. D. Eazhisai, and S. Netaji, Hepatoprotective Activity of Boerhavia diffusa against paracetamol induced toxicity in rats. Journal of Chemical & Pharmaceutical Research. 2011; vol. 3, pp. 229–232
  9. K. S. Rawat, S. Mehrotra, S. C. Tripathi, and U. Shome. Hepatoprotective activity of Boerhaavia diffusa L. roots—a popular Indian ethnomedicine. Journal of Ethnopharmacology. 1997; vol. 56, no. 1, pp. 61–66.
  10. Beedimani RS, Jeevangi SK. Evaluation of hepatoprotective activity of Boerhaavia diffusa against carbon tetrachloride induced liver toxicity in albino rats. Int J Basic Clin Pharmacol 2015; 4:153-8.
  11. Devaki, K. S. Shivashangari, V. Ravikumar, and P. Govindaraju. Effect of Boerhaavia diffusa on tissue anti-oxidant defense system during ethanol-induced hepatotoxicity in rats. Journal of Natural Remedies. 2005; vol. 5, no. 2, pp. 102–107.
  12. Nalini G, Ajithadasaruna, Chidambaranathan N and Jegan N. Hepatoprotective activity of hydroalcoholic extract of Boerhaavia diffusa linn against d-galactosamine induced hepatotoxicity in mice. Int J Pharm Sci Res 2018; 9(8): 3367-72. doi: 10.13040/IJPSR.0975-8232. 9(8).3367-72
  13. Ebere Orish, Orish E Orisakwe, Onyenmechi Johnson, Chudi Emma Dioka, Sub-chronic Toxicity Studies of the Aqueous Extract of Boerhavia diffusa Leaves, 2003,  Journal of health science 49(6):444-447
  14. Singh A, Singh RG, Singh RH, Mishra N, Singh N, An experimental evaluation of possible teratogenic potential in Boerhavia diffusa in albino rats. Planta Med. 1991; 57,315-316
  15. Gilani AH, Janbaz KH. Evaluation of the liver protective potential of Cichorium intybus seed extract on acetaminophen and CC14-induced damage. Phytomedicine. 1994;1(3):193–197
  16. Gilani AH, Janbaz KH, Shah BH. Esculetin prevents liver damage induced by paracetamol and CCL4. Pharmacological Research. 1998;37(1):31–35
  17. Gadgoli C, Mishra SH. Antihepatotoxic activity of Cichorium intybus. Journal of Ethnopharmacology. 1997; 58(2):131–134.
  18. Souad Elgengaihi,Abdel-Tawab H. Mossa,Amel A. Refaie &Doha Aboubaker, Hepatoprotective Efficacy of Cichorium intybus L. Extract Against Carbon Tetrachloride-induced Liver Damage in Rats. Journal of Dietary Supplements. 2016;Volume 13, - Issue 5, Pages 570-584
  19. Bhaskara Reddy Nallamilli Ch.S.Phani Kumar K.Veer Reddy M.Lakshmi Prasanna V.Maruthi P.Sucharita, Hepatoprotective activity of Cichorium intybus (Linn.) root extract against carbon tetrachloride induced hepatotoxicity in albino Wistar rats, Drug Invention Today.  December 2013;Volume 5, Issue 4, Pages 311-314
  20. Jamshidzadeh, A., Khoshnood, M., Dehghani, Z., Niknahad, H. Hepatoprotective Activity of Cichorium intybus L. Leaves Extract against Carbon Tetrachloride Induced Toxicity. Iranian Journal of Pharmaceutical Research, 2010; Volume 5(Number 1): 41-46
  21. Zafar R, Mujahid Ali S. Anti-hepatotoxic effects of root and root callus extracts of Cichorium intybus L. Journal of Ethnopharmacology. 1998;63(3):227–231
  22. Ahmed B, Khan S, Masood MH, Siddique AH. Anti-hepatotoxic activity of cichotyboside, a sesquiterpene glycoside from the seeds of Cichorium intybus. Journal of Asian Natural Products Research. 2008;10 (3-4): 223–231.
  23. Hepatoprotective effect of Cichorium intybus L, a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats World J Gastroenterol. 2014; 20(16): 4753–4760.
  24. Ziamajidi N, Khaghania S, Hassanzadeh G, et al. Amelioration by chicory seed extract of diabetes- and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPAR-alpha and SREBP-1. Food and Chemical Toxicology. 2013;58:198–209
  25. Physician’s desk reference [PDR] for Herbal medicines, Medical Economics company, New Jersy, USA 2000, 181-182
  26. Eidi A, Mortazavi P, Bazargan M, Zaringhalam J: Hepatoprotective activity of cinnamon ethanolic extract against CCL 4-induced liver injury in rats. EXCLI J. 2012, 11: 495-507.
  27. El-hadary, Abdalla. Antioxidant and Hepatoprotective effect of Cinnamomum Zeylanicum oil against paracetamol induced hepatotoxicity in male rate. Journal of Agricultural Chemistry and Biotechnology. 2015; 6. 407-418
  28. Mahyar Dorri, Shirin Hashemitabar & Hossein Hosseinzadeh. Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review, Drug and Chemical Toxicology. 2018; 41:3, 338-351
  29. Karamalakova, Y. & Nikolova, Galina & Georgiev, Tzvetelin & Gadjeva, Veselina & Tolekova, Anna. Hepatoprotective properties of Curcuma longa L. extract in bleomycin-induced chronic hepatotoxicity. Drug Discoveries & Therapeutics. 2019; 13. 9-16. 10.5582/ddt.2018.01081.
  30. Singh, I. & Subramaniyan, Vetriselvan & Shankar, J. & Gayathiri, S. & Hemah, C. & Shereenjeet, G. & Yaashini, A. Hepatoprotective activity of aqueous extract of Curcuma longa in ethanol induced hepatotoxicity in albino wistar rats. Int. J. Phytopharmacol. 2012; 3. 226-233
  31. N. Somchit, A. Zuraini, A. Ahmad Bustamam, N. Somchit, M.R. Sulaiman and R. Noratunlina. Protective Activity of Turmeric (Curcuma longa) in Paracetamol-induced Hepatotoxicity in Rats. International Journal of Pharmacology. 2005; 1: 252-256
  32. Baxla SL, Gora RH, Kerketta P, Kumar N, Roy BK and Patra PH. Hepatoprotective effect of Curcuma longa against lead induced toxicity in Wistar rats. 2013; Vet World 6(9): 664-667, doi: 10.14202/vetworld.2013.664-667
  33. Hismiogullari, S.E.; Hismiogullari, A.A.; Sunay, F.B.; Paksoy, S.; Can, M.; Aksit, H.; Karaca, O. Yavuz, O. The protective effect of curcumin on carbon tetrachloride induced liver damage. Revue Méd. Vét. 2014, 165, 194–200.
  34. Eun Jung Kyung et al. Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging Mediators of Inflammation / 2018, 9 pages. https://doi.org/10.1155/2018/5491797
  35. Li, B.; Wang, L.; Lu, Q.; Da, W. Liver injury attenuation by curcumin in a rat NASH model: An Nrf2 activation-mediated effect? J. Med. Sci. 2016, 185, 93–100
  36. Tokaç, M. Taner, G. Aydın, S. Ozkarde¸s, A.B. Dündar, H.Z. Ta¸slıpınar, M.Y. Arıkök, A.T. Kılıç, M. Ba¸saran, A.A. Basaran, N. Protective effects of curcumin against oxidative stress parameters and DNA damage in the livers and kidneys of rats with biliary obstruction. Food Chem. Toxicol. 2013; 61, 28–35
  37. Ghoreshi, Z.A. Kabirifar, R. Safari, F. Karimollah, A. Moradi, A. Eskandari-Nasab, E. Hepatoprotective effects of curcumin in rats after bile duct ligation via downregulation of Rac1 and NOX1. Nutrition 2017, 36, 72–78. 
  38. Lin, C.M. Lee, J.F. Chiang, L.L. Chen, C.F. Wang, D. Su, C.L. The protective effect of curcumin on ischemia-reperfusion-induced liver injury in Transplantation Proceedings; Elsevier: Amsterdam, The Netherlands. 2012; Volume 44, pp. 974–977
  39. Vizzutti, F. Provenzano, A. Galastri, S. Milani, S. Delogu, W. Novo, E.; Caligiuri, A.; Zamara, E. Arena, U.; Laffi, G.; et al. Curcumin limits the fibrogenic evolution of experimental steatohepatitis. Lab. Investig. 2010, 90, 104–115
  40. Ganiger SMalleshappa HNKrishnappa HRajashekhar GRamakrishna Rao VSullivan F.A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats. Food Chem Toxicol. 2007 Jan;45(1):64-9. E pub 2006 Aug 7.
  41. Vijayalaxmi, Genetic effects of turmeric and curcumin in mice and rats. Mutat Res. 1980,79,125-132
  42. Sharma RA, Steward WP, Gescher AJ, Pharmacokinetics and pharmacodynamics of curcumin. Adv Exp Med Biol. 2007; 595:453-70.
  43. Sreenivasa Rao Damarla, Rajesh Komma, Upendra Bhatnagar, Navin Rajesh, Sadik Mohmad Abdulhamid Mulla. An Evaluation of the Genotoxicity and Subchronic oral Toxicity of Synthetic Curcumin. Journal of Toxicology. Volume 2018, 27 pages
  44. Mitali Das, Alaka Das, Evaluation of Hepatoprotective Activity of Cuscuta Reflexa Roxb. Stem On Experimental Animals. Indian Journal of Applied Research. 2017; Volume, Issue.
  45. Amaresh, Panda & Seemanchala, Rath & Debashis, Pradhan & Mahanty, Arpan & Kumar, Gupta & Bala, Nripendra. Hepatoprotective Activity of Whole Part of the Plant Cuscuta reflexa Roxb. (Convolvulaceae) in Chloroform, Ethanol and Paracetamol Induced Hepatotoxic Rat Models. International Journal of Pharmaceutical and Clinical Research.  2014;6. 127-132
  46. Shweta Mishra, Niraj Dixit, Investigations on hepatoprotective effect of extract in Paracetamol Cuscuta reflexa induced toxicity Asian Journal of Pharmacy and Pharmacology 2019; 5(4):750-754
  47. Nishant Singh Katiyar, Amrit Pal Singh , Saravanan K , Anil Kumar Gangwar , N. Venkat Rao, Evaluation of hepatoprotective activity of stem extracts of Cuscuta reflexa (roxb) on thioacetamide induced liver damage in rats, World J Pharm Sci 2015; 3(5): 872-877
  48. Arun K, Balasubramanian U., Comapartive Study on Hepatoprotective activity of Phyllanthus amarus and Eclipta prostrata against alcohol induced in albino rats. International journal of environmental sciences 2011, 2(1), 361-379.
  49. K. Saxena, B. Singh,  K. K. Anand. Hepatoprotective effects of Eclipta alba on subcellular levels in rats. Journal of Ethnopharmacology. 1993. vol. 40, no. 3, pp. 155–161.
  50. Singh, A. K. Saxena, B. K. Chandan, S. G. Agarwal, K. K. Anand, In vivo hepatoprotective activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian Journal of Physiology and Pharmacology. 2001; vol. 45, no. 4, pp. 435–441.
  51. Singh, A. K. Saxena, B. K. Chandan, S. G. Agarwal, M. S. Bhatia, and K. K. Anand, “Hepatoprotective effect of ethanolic extract of Eclipta alba on experimental liver damage in rats and mice,” Phytotherapy Research, vol. 7, no. 2, pp. 154–158, 1993.
  52. Zafar and B. P. S. Sagar. Hepatoprotective and cardiac inhibitory activities of ethanolic extracts from plant leaves and leaf callus of Eclipta alba. Pharmaceutical Biology. 2000. vol. 38, no. 5, pp. 357–361.
  53. Thirumalai, E. David, V. Therasa, E. K. Elumalai. Restorative effect of Eclipta alba in CCl4 induced hepatotoxicity in male albino rats. Asian Pacific Journal of Tropical Disease. 2011; vol. 1, no. 4, pp. 304–307.
  54. Prabu K, Kanchana N, Sadiq AM., Hepatoprotective effect of Eclipta alba on paracetamol induced liver toxicity in rats. Journal of Microbiology and Biotechnology Research. 2011, 1 (3), 75-79.
  55. R. Parmar, P. H. Vashrambhai, and K. Kalia. Hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in rats.  Journal of Herbal Medicine and Toxicology.2010; vol. 4, pp. 101–106.
  56. Kumar, A. K. Katiyar, M. Swamy, Y. P. Sahni, and S. Kumar. Hepatoprotective effect of Eclipta alba on experimentally induced liver damage in rats. Indian Journal of Veterinary Pathology. 2013; vol. 37, pp. 159–163.
  57. Mogre K, Vora KK, Sheth UK. Effect of Picrorhiza kurro and Eclipta alba on Na+/K+ATPase in hepatic injury by hepatotoxic agenta.  Indian JPharmacol. 1981, 13 253-259
  58. N. Murthy, B. P. Reddy, V. Venkateshwarlu, and C. K. Kokate, Antihepatotoxic activity of Eclipta alba, Tephrosia purpureaand Boerhaavia diffusa, Ancient Science of Life. 1992; vol. 11, pp. 182–186,
  59. Lin SC, Yao CJ, Lin CC, Lin YH. Hepatoprotective Activity of Taiwan Folk Medicine: Eclipta prostrata Linn against Various Hepatotoxins Induced Acute Hepatotoxicity. Phytotherapy Research 1998, 10(6), 483 - 490.
  60. K. Lal, A. Kumar, P. Kumar, and K. S. Yadav, Screening of leaves and roots of Eclipta alba for hepatoprotective activity. Archives of Applied Science Research. 2010; vol. 2, no. 1, pp. 86-94
  61. Wagner, B. Geyer, Y. Kiso, H. Hikino, and G. S. Rao. Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulacea. Planta Medica. 1986 ; vol. 5, pp. 370–374.
  62. Manvar, M. Mishra, S. Kumar, and V. N. Pandey. Identification and evaluation of anti hepatitis C virus phytochemicals from Eclipta alba.  Journal of Ethnopharmacology.  2012; vol. 144, no. 3, pp. 545–554
  63. Thilakchand KR, Mathai RT, Simon P, Ravi RT, Baliga-Rao MP, Baliga MS. Hepatoprotective properties of the Indian gooseberry (Emblica officinalis Gaertn): a review. Food Funct. 2013 Oct;4(10):1431-41. doi: 10.1039/c3fo60237k. PMID: 23978895
  64. Damodara Reddy V, Padmavathi P, Gopi S, Paramahamsa M, Varadacharyulu NCh. Protective effect of Emblica officinalis against alcohol‑induced hepatic injury by ameliorating oxidative stress in rats. Indian J Clin Biochem 2010; 25:419‑24.
  65. Reddy VD, Padmavathi P, Varadacharyulu NCh. Emblica officinalis protects against alcohol‑induced liver mitochondrial dysfunction in rats. J Med Food 2009; 12:327‑33.
  66. Sharma A, Sharma MK, Kumar M. Modulatory role of Emblica officinalis fruit extract against arsenic induced oxidative stress in Swiss albino mice. Chem Biol Interact 2009;180:20‑30.
  67. Mir AI, Kumar B, Tasduq SA, Gupta DK, Bhardwaj S, Johri RK. Reversal of hepatotoxin‑induced pre‑fibrogenic events by Emblica officinalis – A histological study. Indian J Exp Biol 2007; 45:626‑9.
  68. Sultana S, Ahmed S, Sharma S, Jahangir T. Emblica officinalis reverses thioacetamide‑induced oxidative stress and early promotional events of primary hepatocarcinogenesis. J Pharm Pharmacol 2004; 56:1573‑9.
  69. Tasduq SA, Mondhe DM, Gupta DK, Baleshwar M, Johri RK. Reversal of fibrogenic events in liver by Emblica officinalis (fruit), an Indian natural drug. Biol Pharm Bull. 2005; 28:1304‑6.
  70. Sultana S, Ahmad S, Khan N, Jahangir T. Effect of Emblica officinalis (Gaertn) on CCl4 induced hepatic toxicity and DNA synthesis in Wistar rats. Indian J Exp Biol 2005;43:430‑6
  71. Tasduq SA, Kaisar P, Gupta DK, Kapahi BK, Maheshwari HS, Jyotsna S, et al. Protective effect of a 50% hydroalcoholic fruit extract of Emblica officinalis against anti‑tuberculosis drugs induced liver toxicity. Phytother Res 2005; 19:193‑7.
  72. Malar H. L. Bai SMM, Hepatoprotective activity of Phyllanthus emblica against paracetamol induced hepatic damage in wistar albino rats. African Journal of Basic and Applied science. 2009;[1-2], 21-25
  73. Gulati RK, Agarwal S, Hepato protective studies on Phtllanthus emblica Linn and quercetin, Indian Journal of Experimental Biology. 1995. 33 [4] ,261-8
  74. Chen KH, Lin BR, Chien CT, Ho CH. Emblica officinalis Gaertn attentuates N‑nitrosodiethylamine‑induced apoptosis, autophagy, and inflammation in rat livers. J Med Food 2011;14:746‑55
  75. Jeena KJ, Joy KL, Kuttan R. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett. 1999 Feb 8;136(1):11-6. doi: 10.1016/s0304-3835(98)00294-8. PMID: 10211933.
  76. Hai Zhong HuoBing WangYong Kang LiangYong Yang Bao,  Yan  Gu. Hepatoprotective and Antioxidant Effects of Licorice Extract against CCl4-Induced Oxidative Damage in RatsInt J Mol Sci. 2011; 12(10): 6529–6543.
  77. Yin, Guojun & Cao, Liping & Xu, Pao & Jeney, Galina & Nakao, Miki & Lu, Chengping. Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl4)-induced hepatocyte damage in common carp (Cyprinus carpio). Fish physiology and biochemistry. 2011; 37. 209-16.
  78. Sharma V, Agrawal RC (2014) In vivo antioxidant and hepatoprotective potential of Glycyrrhiza glabra extract on carbon tetra chloride (CCl4) induced oxidative stress mediated hepatotoxicity. Int J Res Med Sci 2:314–320
  79. Abd-Al-Sattar L and Laylani S. Hepatoprotective effect of Glycyrrhiza glabra L. extracts against carbon tetrachloride-induced acute liver damage in rats. International Journal of Veterinary Science, Medicine & Research 2016; 1(1): 1-8.
  80. Al-Razzuqi RAM, Al-Jawad FH, Al-Hussaini JA, Al-Jeboori AA. Hepato-protective effect of Glycyrrhiza glabra in carbon tetrachloride-induced model of acute liver injury. J Phys Pharm Adv 2012; 2(7): 259-263
  81. Moon A and Kim SH. Effect of Glycyrrhiza glabra roots and glycyrrhizin on the glucuronidation in rats. Planta Med 1997; 63(2):115-119
  82. Sato H, Goto W, Yamamura J, Kurokawa M, Kageyama S, Takahara T, Watanabe A, Shiraki K. Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antivir Res. 1996;  30:171–177 
  83. Van Rossum TG, Vulto AG, De Man RA, Brouwer JT, Schalm SW. Glycyrrhizin as a potential treatment of chronic hepatitis C. Aliment Pharmacol Ther. 1998; 12:199–205
  84. Jeong HG, You HJ, Park SJ, Moon AR, Chung YC, Kang SK, Chun HK. Hepatoprotective effects of 18β-glycyrrhetinic acids on carbon tetrachloride-induced liver injury, inhibition of cytochrome P450 2E1 expression. 2002; Pharmacol Res 46(3):221–227
  85. Tu CT, Li J, Wang FP, Li L, Wang JY, Jiang W, Glycyrrhizin regulates CD4+T cell response during liver fibrogenesis via JNK, ERK and PI3K/AKT pathway. Int Immunopharmacol. 2012 Dec; 14(4):410-21
  86. Sato H, Kageyama S, Yamamoto H, et al. Glycyrrhizin renders cells resistant to apoptosis induced by human and feline immunodeficiency virus. Journal of Traditional Medicines. 2011; 28(3):139–148. 
  87. Abe N, Ebina T, Ishida N. Interferon induction by glycyrrhizin and glycyrrhetinic acid in mice. Microbiology and Immunology. 1982; 26(6):535–539. 
  88. Epstein MT.Espiner EA,Donald RA, Hughes H. Effect of eating liquorice on the renin- angiotensin alsosterone axis in normal subjects. Br Med J. 1977;1,488-490
  89. Bahar Ahmed, Tanveer Alam, Shah A Khan, Hepatoprotective Activity Of Luffa EchinataFruits,Journal Of Ethnopharmacology, Volume 76, Issue 2, 2001; Pages 187-189
  90. P Lauria, VN Sharma, S Vanjani, BC Sangal. The Effect of Luffa Echinata in Liver Injury. J. Pharmac. 1976; 8 (2) 129-L 33.
  91. Jakhmola V, Pawar VK, Lal VK. Hepatoprotective Effect of Acetone Extract Of Luffa Echinata Root Against Carbon Tetrachloride Induced Liver Injury In Rats. Pharmacologyonline 2010; 1: 849-855
  92. Bapat SK, Chandra V. The effect of Luffa echinata (Roxb) on experimental jaundice in rats. Indian J Physiol Pharmacol 1968; 12(3): 119-120.
  93. Richa Dogar, Dr. S. K. Yadav, Dr. B.P. Nagori, Dr. K. Mathur, Dr. M. Goyal. Hypoglycaemic Effect of Luffa Echinata In Alloxan Induced Diabetic Rats. Indian Journal of Drugs. 2018; 6(4), 201-217
  94. Toppo R, Roy BK, Gora RH, Baxla SL, Kumar P. Hepatoprotective activity of Moringa oleifera against cadmium toxicity in rats. Vet World. 2015;8(4):537-540. doi:10.14202/vetworld.2015.537-540
  95. Abdel Fattah ME, Sobhy HM, Reda A, Abdelrazek HMA. Hepatoprotective effect of Moringa oleifera leaves aquatic extract against lead acetate-induced liver injury in male Wistar rats. Environ Sci Pollut Res Int. 2020 Dec;27(34):43028-43043. doi: 10.1007/s11356-020-10161-z. Epub 2020 Jul 28. PMID: 32725563.
  96. Pari L, Kumar NA. Hepatoprotective activity of Moringa oleifera on antitubercular drug-induced liver damage in rats. J Med Food. 2002 Fall;5(3):171-7
  97. Aly, O., Abouelfadl, D.M., Shaker, O.G. et al. Hepatoprotective effect of Moringa oleifera extract on TNF-α and TGF-β expression in acetaminophen-induced liver fibrosis in rats. 2020; Egypt J Med Hum Genet 21
  98. Mbagwu, Herbert, EtokNsikan, &EkpoEmem. Hepatoprotective activity of the methanolic leaf extract of Moringa oleifera (Lam) against chemically-induced Liver Toxicity. International Journal of Pharmacology and Toxicology [Online], 4.1 (2016): 40-46
  99. Farrag AR, Mahdy KA, Abdel Rahman GH, Osfor MM. Protective effect of Nigella sativa seeds against lead-induced hepatorenal damage in male rats. Pak J Biol Sci. 2007 Sep 1;10(17):2809-16. doi: 10.3923/pjbs.2007.2809.2816. PMID: 19090181.
  100. Chatterjee M, Sil PC. Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo. Indian J Biochem Biophys. 2006 Oct;43(5):299-305. PMID: 17133737.
  101. Renuka MR, Rahim S. Hepatoprotective Effect of Phyllanthus Niruri Aqueous Extract on Paracetamol Induced Stress in the Fish Anabas Testudineu , International Journal of Information Research and Review. November, 2017; Vol. 04, Issue, 11, pp.4705-4707
  102. Kanter M, Coskun O, Budancamanak M, Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloride-treated rats.World J Gastroenterol. 2005 Nov 14; 11(42):6684-8.
  103. Yildiz F, Coban S, Terzi A, Ates M, Aksoy N, Cakir H, Ocak AR, Bitiren M. Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver.World J Gastroenterol. 2008 Sep 7; 14(33):5204-9.
  104. El-Sayed WM. Upregulation of chemoprotective enzymes and glutathione by Nigella sativa(black seed) and thymoquinone in CCl4-intoxicated rats. Int J Toxicol. 2011; 30:707–714. 
  105. Nagi MN, Almakki HA, Sayed-Ahmed MM, Al-Bekairi AM. Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver. Food Chem Toxicol. 2010;48:2361–2365
  106. Talib WH, Abukhader MM. Combinatorial effects of thymoquinone on the anti-cancer activity and hepatotoxicity of the prodrug CB 1954. Sci Pharm. 2013; 81:519–530. 
  107. Aycan IO, Tufek A, Tokgoz O, Evliyaoglu O, Firat U, Kavak GO, et al. Thymoquinone treatment against acetaminophen-induced hepatotoxicity in rats. Int J Surg. 2014; 12:213–218. 
  108. Sayed-Ahmed, Mohamed M et al. Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling. Oxidative medicine and cellular longevity 3, 4 (2010): 254-61. doi:10.4161/oxim.3.4.12714
  109. Al-Ali A, Alkhawajah AA, Randhawa MA, Shaikh NA, Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats.J Ayub Med Coll Abbottabad. 2008 Apr-Jun; 20(2):25-7.
  110. Khader M, Bresgen N, Eckl PM, In vitro toxicological properties of thymoquinone., Food Chem Toxicol. 2009 Jan; 47(1):129-33
  111. Zaoui A, Cherrah Y, Mahassini N, Alaoui K, Amarouch H, Hassar M, Acute and chronic toxicity of Nigella sativa fixed oil. 2002 Jan; 9(1):69-74
  112. Wongnawa, M., Thaina, P., Bumrungwong, N., Nitiruangjarat, A., Muso, A., Prasartthong, V. 2005. Congress on Medicinal and Aromatic Plants. – Vol. 6: Traditional Medicine and Nutraceuticals. ISHS Acta Horticulturae 680. 17660/ActaHortic.2005.680.30
  113. Surya Narayanan, B., Latha, P., Rukkumani, R. Protective effects of Phyllanthus amarus on fibrotic markers during alcohol and polyunsaturated fatty acid-induced toxicity. Toxicology Mechanisms and Methods 2011; 21, 48–52
  114. Syed Asad B, Iqbal MM, Kiranmai M, Ibrahim M. Hepatoprotective Activity of Phyllanthus Amarus Seeds Extracts in CCl4 Treated Rats: In vitro & In Vivo. Global Journal of Medical Research.2012; 12(6):39-49.
  115. Visweswaram, D., Rao, P.R., Satyanarayana, S., 1994. A noninvasive method for screening hepatoprotective drugs against carbon tetrachloride-induced hepatotoxicity. Indian Journal of Pharmacology 26, 301–303.
  116. Krithika, A., Verma, R.R.J., 2009b. Mitigation of carbon tetrachloride induced damage by Phyllanthus amarus in liver of mice. Acta Poloniae Pharmaceutica – Drug Research 66, 439–445.
  117. Krithika, A.R., Verma, R.J., 2009a. Ameliorative potential of Phyllanthus amarus against carbon tetrachloride induced hepatotoxicity. Acta Poloniae Pharmaceutica – Drug Research 66, 579–583
  118. Naaz, F., Javed, S., Abdin, M.Z., 2007. Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum.et.Thonn.on afltoxin B1-induced liver damage in mice. Journal of Ethnopharmacology 113, 503–509
  119. Zahra A. Amin, Mehmet Bilgen, Mohammed A. Alshawsh, Hapipah M. Ali, A. Hamid A. Hadi, and Mahmood A. AbdullaProtective Role of Phyllanthus niruriExtract against Thioacetamide-Induced Liver Cirrhosis in Rat Model, Evidence-Based Complementary and Alternative Medicine.  2012 
  120. Faremi, T.Y, Suru, S.M., Fafunso, M.A., Obioha, U.E. Hepatoprotective potentials of Phyllanthus amarus against ethanol induced oxidative stress in rats. Food and Chemical Toxicology. 2008; 46, 2658–2664
  121. Joshi, C.S., Priya, E.S. Glucuronidase inhibitory effect of phenolic constituents from Phyllanthus amarus. Pharmaceutical Biology. 2007; 45, 363–365.
  122. Ezzat MI, Okba MM, Ahmed SH, El-Banna HA, Prince A, Mohamed SO, et al. In-depth hepatoprotective mechanistic study of Phyllanthus niruri: In vitroand in vivo studies and its chemical characterization. PLoS ONE.2020; 15(1)
  123. Bhattacharjee R, Sil PC. Protein isolate from the herb, Phyllanthus niruri, protects liver from acetaminophen induced toxicity. Biomedical Research. 2006; 17(1):75-79.
  124. Sabir SM, Rocha JBT. Water extractable phytochemical from Phyllanthus niruri exhibit distinct in vitro antioxidant and in vivo hepatoprotective activity against paracetamol induced liver damage in mice. Food chemistry, 2008; 111:845-851
  125. Pramyothin P, Ngamtin C, Poungshompoo S, Chaichantipyuth C. Hepatoprotective activity of Phyllanthus Amarus Schum. Thonn extract in ethanol treated rats: in vitro and in vivo studies. Journal of Ethnopharmacology 2007; 114(2):169-173
  126. Praveen Kumar and Shukla, S.K. Hepatoprotective Efficacy of Picrorhiza kurroa in experimentally induced Hepatotoxicity in Cockerels. Int.J.Curr.Microbiol.App.Sci. 2017; 6(4): 2614- 2622
  127. Sinha S, Bhat J, Joshi M, Sinkar V, Ghaskadbi S. Hepatoprotective activity of Picrorhiza kurroa Royle Ex.  Benth  extract  against  alcohol  cytotoxicity  in  mouse  liver  slice    Int  J  Green  Pharm  2011;5:244-53
  128. Sapna N. ShettySushma MengiRama Vaidya, and Ashok D. B. VaidyaA study of standardized extracts of Picrorhiza kurroaRoyle ex Benth in experimental nonalcoholic fatty liver disease, J Ayurveda Integr Med. 2010 Jul-Sep; 1(3): 203–210.
  129. Rastogi  R,  Saksena  S,  Garg  NK,  Kapoor  NK,  Agarwal  DP,  Dhawan    Picroliv protects against alcohol-induced chronic hepatotoxicity in rats. Planta Med 1996;62:283-5.14
  130. Visen PK, Shukla B, Patnaik JK. Hepatoprotective activity of Picroliv. The active principle of Picrorhiza kurroa on rat hepatocytes against paracetamol toxicity. Drug Dev Res 1991;22:209-10
  131. Shukla B, Visen PK, Patnaik GK, Dhawan BN. Choleretic effect of picroliv, the hepatoprotective principle of Picrorhiza kurroa. Planta Med 1991; 57:29-33.15.
  132. Dwivedi Y. Rastogi R. Mehtorta R Garg NK, Dhawan BN, Picoliv protects against aflatoxin B1 acute hepatotoxicity in rats. Pharmacol Res 1993,27 189-199
  133. Ravi Rastogi , Seema Saksena, K. Garg, B. N. Dhawan Effect of picroliv on antioxidant‐system in liver of rats, after partial hepatectomy. Phytotherapy research. August 1995;Volume 9, Issue5, ,, Pages 364-367
  134. Praveen C. Verma, Vaishali Basu, Vijayta Gupta, Gauri Saxena, Laiq Ur Rahman. Pharmacology and Chemistry of a Potent Hepatoprotective Compound Picroliv Isolated from the Roots and Rhizomes of Picrorhiza kurroa Royle ex Benth. (Kutki), Current Pharmaceutical Biotechnology. 2009;Volume 10 (6).
  135. Singh M, Tiwari V, Jain A, Ghoshal Protective activity of picroliv on hepatic amoebiasis associated with carbon tetrachloride toxicity. Indian J Med Res. 2005 May; 121(5):676-82.
  136. Chander RDwivedi YRastogi RSharma SKGarg NKKapoor NKDhawan BN, Evaluation of hepatoprotective activity of picroliv (from Picrorhiza kurroa) in Mastomys natalensis infected with Plasmodium berghei, Indian J Med Res.1990 Feb;92:34-7.
  137. Chander R, Kapoor NK, Dhawan BN. Picroliv affects gamma-glutamyl cycle in liver and brain of Mastomys natalensis infected with Plasmodium berghei. Indian J Exp Biol. 1994 May; 32(5):324-7.
  138. Chander R, Kapoor NK, Dhawan BN , Effect of picroliv on glutathione metabolism in liver and brain of  Mastomys natalensis infected with Plasmodium berghei. Indian J Exp Biol. 1992 Aug; 30(8):711-4.
  139. Anasari RA. et al. Hepatoprotective activity of Kutkin- the iridoid glycoside mixture of Picrorhiza kurrooa. Indian J Med Res. 1988;87,401-404
  140. Patel, Jagruti & SHAH, Urvi. (2009). Hepatoprotective activity of Piper longum traditional milk extract on carbon tetrachloride induced liver toxicity in Wistar rats. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas. 8.
  141. Kesarwani K, Gupta R, Mukerjee A. Bioavailability enhancers of herbal origin: an overview. Asian Pac J Trop Biomed. 2013; 3(4):253–266.
  142. O Abdel Salam, S Nofal, S El-Shenawy, N Shaffie. Effect of Piperine on Liver Damage and Bone Changes Caused By Bile Duct Ligation In Rats. The Internet Journal of Pharmacology.2007 Volume 5 Number 2.
  143. Mananvalan G and Singh J. Chemical and some pharmacological studies on leaves of P.longum Linn., Indian J. Sci  1979; 41:190
  144. Pawinee PiyachaturawatThirayudh GlinsukonChaivat Toskulkao, Acute and subacute toxicity of piperine in mice, rats and hamsters, Toxicology Letters. 1983;Volume 16, Issues 34, Pages 351-359
  145. Tayubi IA, Desai A, Madar IH, Al Sadh H. Hepatoprotective activity of plumbago zeylanica linn. Against carbon tetrachloride induced heaptotoxicity in rats. Int J Sci Innovs, 2018; 5 (2): 094-098.
  146. Kumar R, Kumar S, Patra A, Jayalakshmi S (2009). Hepatoprotective activity of aerial parts of Plumbago zeylanica linn against carbon tetrachloride-induced hepatotoxicity in rats. Int. J. Pharma. Pharm. Sci. 2009; 1: 171-175
  147. Kanchana And A. Mohamed Sadiq, Hepatoprotective Effect Of Plumbago Zeylanica On Paracetamol Induced Liver Toxicity In Rats, International Journal of Pharmacy and Pharmaceutical Sciences. 2011; Vol 3, Issue 1.
  148. Kumar Patil, Roy S.Kholkute SD, Hegde HV, Nair V. Comparative toxicity profiles of Pulmbago zeylanica L. root pterolleum ether, acetone and hydroalcoholic extracts in Wistar rats. AYU 2015:36:329-34
  149. Nagalekshmi R., Menon A., Chandrasekharan D. K., Nair C. K. K. Hepatoprotective activity of Andrographis paniculata and Swertia chirayita. Food Chem. Toxicol. 2011; 49:3367–3373.
  150. Karan M, Vasisht K, Handa S.S., Antihepatotoxic activity of Swertia chirata on paracetamol and galactosamine induced hepatotoxicity in rats. Phytotherapy Research. 1999; 13(2), 95-01
  151. Chakravaty AK, Mukhopadhyay S. Moitra SK, Das B Syringaresinol, a hepatoprotective agent and other constituents fom Swertia chirayita. Indian J. Chem. 1994; 33B 405-408
  152. Mukherjee S, Sur A, Maiti B.R., Hepatoprotective effect of Swertia chirata on rat. Indian J Exp Biol., 1997, 35(4), 384-8.
  153. Gunjegaonkar SM, Kshirsagar SS, Bayas JP. Hepatoprotective and Antioxidant potential of Tephrosia Purprea in Paracetamol Induced Hepatotoxicity. Int J of Pharmc Res [Internet]. 2016 Mar. 30; 6(3):104-8.
  154. Shah et al Evaluatioof Hepatoprotective Activity of Ethyl Acetate Fractio of Tephrosia Purpurea.    2011;  3: 188-194     
  155. Ravuri Halley Gora, Sushma Lalita Baxla, Priscilla Kerketta, Subhasree Patnaik, Birendra Kumar Roy, Hepatoprotective activity of Tephrosia purpurea against arsenic induced toxicity in rats, Indian J Pharmacol. 2014 Mar-Apr; 46(2): 197–200. doi: 10.4103/0253-7613.129317
  156. Khatri A, Garg A, Agrawal SS Evaluation of hepatoprotective activity of aerial parts of Tephrosia purpurea L. and stem bark of Tecomella undulata, Journal of Ethnopharmacology, 18 Nov 2008, 122(1):1-5
  157. Tasduq, S.A., K. Singh, N.K. Satti, D.K. Gupta, K.A. Suri and R.K. Johri.Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination. Hum. Exp. Toxicol. 2006; 25: 111  
  158. Srisesharam Srigopalram, Indira A Jayraaj, Effect of Terminalia Chebula Retz on Den Induced Hepatocellular Carcinogenesis In Experimental Rats, International Journal of Pharmacy and Pharmaceutical Sciences. 2012. 4(2).
  159. Min-Kyung Choi, Hyeong-Geug Kim Jong-Min Han, Jin-Seok Lee, Jong Suk Lee, Sun Ho Chung, and Chang-Gue Son, Hepatoprotective Effect of Terminalia chebulaagainst t-BHP-Induced Acute Liver Injury in C57/BL6 Mice. Evidence-Based Complementary and Alternative Medicine. 2015
  160. Tania Yeasmin, Qazi Shamima Akhter, Syeda Tasfia Siddika, Fayeza Karim. Effect of Terminalia Chebula (Haritaki) on Serum Aspartate Aminotransferase, Alanine Aminotransferase in Paracetemol induced liver damage in Wister Albino Rats, J Bangladesh Soc Physiol. 2015, June; 10(1): 1-5
  161. V, B., and L. T. Hepatoprotective Activity Of Ethanolic Extract Of Terminalia Chebula Fruit Against Ethanol Induced Hepatotoxicity In Rats”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 11, Nov. 2017, pp. 55-58,
  162. Lee H.-S., Jung S.-H., Yun B.-S., Lee K.-W.Isolation of chebulic acid from Terminalia chebulaand its antioxidant effect in isolated rat hepatocytes. Archives of Toxicology. 2007;81(3):211–218
  163. Hussein R. H., Khalifa F. K. The protective role of ellagitannins flavonoids pretreatment against N-nitrosodiethylamine induced-hepatocellular carcinoma. Saudi Journal of Biological Sciences. 2014; 21(6):589–596.
  164. Rathore, H. A Study on the Cytological Effects of Myrobalan (Fruit of Terminalia chebula ) in Allium Tests. Ethnobotanical Leaflets, 2006, 9.
  165. Arora, E. Brits, S. Kaur, K. Kaur, R.S. Sohi, S. Kumar, L. Verschaeve L. Evaluation of genotoxicity of medicinal plant extracts by the Comet and VITOTOX tests. J. Environ. Pathol.Toxicol.Oncol. 2005; 24(3) : 193-200 .
  166. Stance MH, A Nagy A., Tosa M., Vlad L. Hepatoprotective effect of orally administered melatonin & Tinospora cordifolia in experimental jaundice. Chirurgia (bucur) 2011; 106(2), 205-10
  167. PEER F, Sharma PC. Tinospora Cordifolia in CCl4 induced Hepatopathy in Goats. Indian Journal Vet. Med 1989; 9 154-156
  168. Sharma B, Dabur R. Protective Effects of Tinospora cordifolia on Hepatic and Gastrointestinal Toxicity Induced by Chronic and Moderate Alcoholism. Alcohol Alcohol. 2016 Jan; 51(1):1-10. doi: 10.1093/alcalc/agv130. Epub 2015 Nov 19. PMID: 26589585.
  169. Nagarkatti DS1, Rege NN, Desai NK, Dahanukar SA. Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. J Postgrad Med. 1994; Apr-Jun;40(2):65-7.
  170. T. KavithaS. D. ShruthiS. Padmalatha Rai, and Y. L. RamachandraPhytochemical analysis and hepatoprotective properties of Tinospora cordifoliaagainst carbon tetrachloride-induced hepatic damage in rats, J Basic Clin Pharm. June -August 2011; 2(3): 139–142.
  171. Kumar, V. & Modi, P.K. & Saxena, K.K.Exploration of hepatoprotective activity of aqueous extract of Tinospora cordifolia - An experimental study.Asian Journal of Pharmaceutical and Clinical Research.2013; 87-91.
  172. Singh B, Sharma ML, Gupta DK, Atal CK, Arya RK, Protective effect of Tinospora cordifolia Miers on Carbon tetrachloride induced hepatotoxicity. Indian J Pharmacol 1984, 16 139-142
  173. Rege N,   Dahanukar   S   &   Karandikar   S   M,   Hepatotoxic   Effects   of   Tinospora   cordifolia against    carbon    tetrachloride    induced    liver    damage, Indian Drugs. 1984; 21(12) 544
  174. Kokate CK & Rambhau D, Antihepatotoxic Activity    of    Phyllanthus    niruri,    Tinospora    cordifolia and Ricinus communis, Indian Drugs.1993; 30(7) 338.
  175. Latha U,    Rajesh    M    G    &    Latha    M    S,    Hepatoprotective    Effect    of    an    Ayurvedic    Medicine, Indian Drugs. 1999;  36(7), 470
  176. Pandey Protective role of Tinospora cordifolia against lead-induced hepatotoxicity Toxicol. Int. 2010; 17 pp. 12-17
  177. Gupta, V. SharmaA meliorative effects of Tinospora cordifolia root extract on histopathological and biochemical changes induced by aflatoxin-b in mice kidney Toxicol. Int.  2011; 18 pp. 94-98
  178. Ezeonu CS, Egbuna PAC, Ezeanyika LUS, Nkwonta CG, Idoko ND, Antihepatotoxicity studies of crude extract of Zingiber officinale on CCl4 induced toxicity and comparison of the extract’s fraction D hepatoprotective capacity, Research Journal of Medical Sciences. 2011; 5(2), 102-107
  179. Yemitan OK, Izegbu MC.Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats.Phytother Res. 2006 Nov; 20(11):997-1002.
  180. Abdullah N, Saat NZM, Hasan HA, Budin SB, Kamaralzaman S, Protective effectof the ethanol extract of Zingiber officinale Roscoe on paracetamol induced hepatotoxicity in rats, Jurnal Sains Kesihatan Malaysia, 2004, 2(2)
  181. Abdulaziz Bardi D, Halabi MF, Abdullah NA, Rouhollahi E, Hajrezaie M, Abdulla MA. In vivo evaluation of ethanolic extract of Zingiber officinale rhizomes for its protective effect against liver cirrhosis. Biomed Res Int. 2013; 2013:918460. doi:10.1155/2013/918460
  182. Abdelgawad Fahmi,Naglaa Hassanen,Mariam Abdur-Rahman&Engy Shams-Eldin,Phytochemicals, antioxidant activity and hepatoprotective effect of ginger (Zingiber officinale) on diethylnitrosamine toxicity in rats, Journal  2019; Volume 24, Issue 5.
  183. Egwurugwu, J. N. Effects of ginger (Zingiber officinale) on cadmium toxicity, African Journal of Biotechnology. 2007 September; Vol. 6 (18), pp. 2078-2082
  184. Jharna Bansal, Nitin Kumar, Rishabha Malviya and Pramod Kumar Sharma. Hepatoprotective Models and Various Natural Product Used in Hepatoprotective Agents: a Review, Pharmacognosy Communications. July–Sep 2014; Volume 4, Issue 3
  185. Yoon, Eric et al. Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update Journal of clinical and translational hepatology. 2016; 4,2. 131-42. doi:10.14218/JCTH.2015.00052
  186. Torrielli MV, Gabriel L, Dianzani MU. Ethanol-induced hepatotoxicity; experimental observations on the role of lipid peroxidation. J Pathol. 1978 Sep; 126(1):11-25. doi: 10.1002/path.1711260103. PMID: 722405
  187. Stephanie Mathews, Mingjiang Xu, Hua Wang, Adeline Bertola, Bin Gao, Animals Models of Gastrointestinal and Liver Diseases. Animal models of alcohol-induced liver disease: pathophysiology, translational relevance, and challenges, Am J Physiol Gastrointest Liver Physiol 306: G819–G823, 2014
  188. MC Wallace , K Hamesch , M Lunova , Y Kim , R Weiskirchen , P Strnad, and SL Friedman, Standard Operating Procedures in Experimental Liver Research: Thioacetamide model in mice and rats, Laboratory Animals 2015, Vol. 49(S1) 21–29
  189. Yew WW, Leung CC. Antituberculosis drugs and hepatotoxicity. Respirology. 2006 Nov;11(6):699-707. doi: 10.1111/j.1440-1843.2006.00941.x. PMID: 17052297
  190. Qadrie ZL, Rajkapoor B and Kavimani S: Hepatoprotective Medicinal Herbs and Animal Models for Their Screening - A Review. Int J Pharm Sci Res 2015; 6(12): 5006-28.doi: 10.13040/IJPSR.0975-8232.6(12).5006-28
  191. Ho DW, Lam DK, Chen YB, To J, Ng IO, Fan ST. Galactosamine-induced fulminant liver failure--observation in a porcine model. Asian J Surg. 2002 Jan;25(1):73-9; discussion 80-1. PMID: 17585450
  192. Tolba R, Kraus T, Liedtke C, Schwarz M, Weiskirchen R. Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice. Lab Anim. 2015 Apr;49(1 Suppl):59-69. doi: 10.1177/0023677215570086. PMID: 25835739
  193. Akshatha GM, Raval SK, Arpitha GM, Raval SH, Ghodasara DJ (2018) Immunohistochemical, histopathological study and chemoprotective effect of Solanum nigrum in N-nitrosodiethylamine-induced hepatocellular carcinoma in Wistar rats, Veterinary World, 11(4): 402-409
  194. Otto Kučera, René Endlicher, Tomáš Roušar, Halka Lotková, Tomáš Garnol, Zdeněk Drahota, Zuzana Červinková,The Effect of tert-Butyl Hydroperoxide-Induced Oxidative Stress on Lean and Steatotic Rat Hepatocytes In VitroOxidative Medicine and Cellular Longevity, vol. 2014, Article ID 752506, 12 pages, 2014. https://doi.org/10.1155/2014/752506
  195. Pamela D. Moore, Clement G. Yedjou, and Paul B. Tchounwou, Malathion-Induced Oxidative Stress, Cytotoxicity and Genotoxicity in Human Liver Carcinoma (HepG2) Cells, Environ Toxicol. 2010 June ; 25(3): 221–226. doi:10.1002/tox.20492
  196. Ibrahim, Nabil M et al. Effect of lead acetate toxicity on experimental male albino rat. Asian Pacific journal of tropical biomedicine. 2012; 2, 1. 41-6. doi:10.1016/S2221-1691(11)60187-1
  197. Bertola A, Mathews S, Ki SH, Wang H, Gao B. Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc. 2013; 8(3):627-637. doi:10.1038/nprot.2013.032
  198. Han, Xiao-Dong et al. The involvement of Nrf2 in the protective effects of (-)-Epigallocatechin-3-gallate (EGCG) on NaAsO2-induced hepatotoxicity.   2017; vol. 8, 39 65302-65312. doi:10.18632/oncotarget.18582
  199. Lv Y, Hu Q, Shi M, Wang W, Zheng Y, Yang Z, Peng L, Bi D, Zhang A, Hu Y. The role of PSMB5 in sodium arsenite-induced oxidative stress in L-02 cells. Cell Stress Chaperones. 2020 May; 25(3):533-540. doi: 10.1007/s12192-020-01104-1. Epub 2020 Apr 16. PMID: 32301004; PMCID: PMC7192974.
  200. Cüre, Medine Cumhur et al. Infliximab Modulates Cisplatin-Induced Hepatotoxicity in Rats. Balkan medical journa. 2016;l 33,5, 504-511. doi:10.5152/balkanmedj.2016.150576
  201. Vásquez-Garzón, V.R., Ramírez-Cosmes, A., Reyes-Jiménez, E. et al.Liver damage in bleomycin-induced pulmonary fibrosis in mice. Naunyn-Schmiedeberg's Arch Pharmacol. 2019; 3921503–1513. https://doi.org/10.1007/s00210-019-01690-7
  202. Renugadevi J, Prabu SM. Cadmium-induced hepatotoxicity in rats and the protective effect of naringenin. Exp Toxicol Pathol. 2010 Mar; 62(2):171-81. doi: 10.1016/j.etp.2009.03.010. Epub 2009 May 5. PMID: 19409769
  203. Kwon J, Kim S, Yoo H, Lee E. Nimesulide-induced hepatotoxicity: A systematic review and meta-analysis. PLoS ONE.2019; 14(1): e0209264. https://doi.org/10.1371/journal.pone.0209264
  204. Singh, Amrit Pal et al. Mechanisms pertaining to arsenic toxicity. Toxicology international 2011;18,2. 87-93. doi:10.4103/0971-6580.84258
  205. Tan X, Xie G, Sun X, Li Q, Zhong W, Qiao P, Sun X, Jia W, Zhou Z. High fat diet feeding exaggerates perfluorooctanoic acid-induced liver injury in mice via modulating multiple metabolic pathways. PLoS One. 2013 Apr 23; 8(4): e61409. doi: 10.1371/journal.pone.0061409. PMID: 23626681; PMCID: PMC3634078
  206. Bhatt Narendra, Deshpande Manasi,   A Comparative Review On Medicinal Plants Used For The Treatment Of Liver Disorders As In Ayurved, Siddha And Unani [Asu] Systems Of Medicine- Part I- Contextual And Clinical Aspects, International journal of Ayurvedic and Herbal medicine,  Vol 11,issue 05, Sep- Oct- 2021
  207. Achliya GS, Wadodkar SG, Dorle AK. Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats. J Ethnopharmacol. 2004 Feb;90(2-3):229-32. doi: 10.1016/j.jep.2003.09.037. PMID: 15013185
  208. Kumar G, Srivastava A, Sharma SK and Gupta YK: Safety evaluation of an Ayurvedic medicine, Arogyavardhini vati on brain, liver and kidney in rats. J Ethnopharmacol, 2012, 140: 151-160.
  209. Jeena K Jose, Ramadasan Kuttan, Hepatoprotective activity of Emblica officinalis and Chyavanaprash, Journal of Ethnopharmacology. 2000; Volume 72, Issues 1–2, 135-140. https://doi.org/10.1016/S0378-8741 (00)00219-1.
  210. Deori C, Das S, Bordoloi SK. Study of hepatoprotective activity of Emblica officinalis (AMLA) in Albino rats. J. Evid. Based Med. Healthc. 2017; 4(54), 3298-3301. DOI: 10.18410/jebmh/2017/655
  211. Dayanand Reddy G, Bernard Mefi M, Bharathy H, Narasimha Kumar GV, Chitikela P Pullaiah, Ganesan R, Sathiya Rajeswaran P. Hepatoprotective Activity of Aruvadha churnam a Traditional Siddha Formulation against Paracetamol Induced Liver Damage in Rats. Research J. Pharm. and Tech. 2018; 11(8): 3380-3384.
  212. Arunmozhi P.et al, Hepatoprotective Activity of Chara Parpam in Ccl4 Induced Rats, IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS). 2013; Volume 5, Issue 6 (Mar. – Apr. 2013), 52-58
  213. Velayudam, Arul Amuthan, Ilavarasan.Hepatoprotective Activity of Kadukkai Maathirai (A Siddha Polyherbal Formulation) Against Carbon Tetrachloride Induced Liver Damage in Rat. Research Journal of Pharmaceutical Sciences. 2012; 1 (4). pp. 17-21.
  214. Kavita Gulati., et al. Hepatoprotective Effects of Dawa-Ul-Kurkum, a Unani Polyherbal Preparation and the Possible Mechanisms in Experimental Model of D-Galactosamine Induced Liver Damage in Rats”. EC Pharmacology and Toxicology. 2019; 7.10, 948-960.
  215. Mehboob Ali, Sagheer Ahmed Khan, Peter S. Chang, Rizwanul Haque, Kanchan Bhatia, Saif Ahmad Habb-e-Asgand, polyherbal Unani formulation, protects liver and antioxidative enzymes against paracetamol induced hepatotoxicity. Pharmaceutical Biology. 2014; 52:4,506-515, DOI: 10.3109/13880209.2013.863949
  216. Shakya AK, Saxena M, Sharma N, Shrivastava S, Shukla S, .Hepatoprotective Efficacy of Sharbat-e- Deenar against carbon tetrachloride- induced liver damage. 2, 2012, J Environ Pathol Toxicol Oncol, 31: 131- 141
  217. Girish et. Al : Hepatoprotective Activity of Herbal Formulations In Liver Toxicity, Indian Journal of Experimental Biology. April 2009; Vol. 47, pp. 257-263
  218. http://www.himalayawellness.com/pro ducts/pharmaceuticals/liv52.
  219. Narayanasamy, V. Selvi. Hepatoprotective effect of a polyherbal formulation (Ayush-Liv.04) against ethanol and CCl4 induced liver damage in rats. Ancient Science of Life. 2005; vol. 25, no. 1, pp. 28–33.
  220. Abul K. Najmi, K. K. Pillai, S. N. Pal, M. Aqil. A. Sayeed. Hepatoprotective and behavioral effects of jigrine in galactosamine-induced hepatopathy in rats, Pharmaceutical Biology. 2010; 48:7, 764-769, DOI: 10.3109/13880200903300188
  221. Mahim Zameer, Abdur Rauf, Iqbal Ahmad Qasm. Hepatoprotective Activity of a Unani Polyherbal Formulation Kabideen in Paracetamol Induced Liver Toxicity in Rats. Hippocratic Journal of Unani Medicine. October - December 2014; Vol. 9 No. 4, Pages 41-50
  222. Debendranath Dey, Sunetra Chaskar, Narendra Bhatt, Deepa Chitre, "Hepatoprotective Activity of BV-7310, a Proprietary Herbal Formulation of Phyllanthus niruriTephrosia purpureaBoerhavia diffusa,and Andrographis paniculata, in Alcohol-Induced HepG2 Cells and Alcohol plus a Haloalkane, CCl4, Induced Liver Damage in Rats", Evidence-Based Complementary and Alternative Medicine, vol. 2020, Article ID 6428906, 9 pages. https://doi.org/10.1155/2020/6428906
  223. Kohli K.R. Tathed P.S., Bhatt N.S, Effect of An Ayurvedic Drug L 2002@ in Viral Hepatitis, The Indian Practitioner, Vol XLVIII, No 7, pp 635-642, July 1995.
  224. Deshpande P.J., Singh R , Bhatt N.S, Clinical Effect of An Ayurvedic Drug L 2002 @ In Hepato-Biliary Disorders, Journal of National Integrated Medical Association, Vol. XXXVI, No.12, pp.5-11, December 1994
  225. S. Bhatt , Banavalikar S, Ghoda M, Evaluation of Hepafyte (A Herral Preparation) for Alcoholic Liver Disease, http://www.drnarendrabhatt.in/researchpapers.html
  226. Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction: A review.  Int Pharm Sci. 2011; 1:98–106.
  227. Pandey A, Tripathi S. Concept of standardization, extraction, and pre-phytochemical screening strategies for herbal drug. J Pharmacogn Phytochem. 2014; 2:115–9. 
  228. Shailajan, M. Joshi, B. Tiwari, Hepatoprotective activity of Parmelia perlata (Huds.) Ach. against CCl4 induced liver toxicity in Albino Wistar rats, J Appl Pharm Sci,  (2014), 4. pp. 70-74.  10.7324/JAPS.2014.40212
  229. Kumar D, Patil PA, Roy S, Kholkute SD, Hegde HV, Nair V. Comparative toxicity profiles of Plumbago zeylanica L. root petroleum ether, acetone and hydroalcoholic extracts in Wistar rats. Ayu. 2015 Jul-Sep;36(3):329-34. doi: 10.4103/0974-8520.182750. PMID: 27313422; PMCID: PMC4895762.

 

IJAHM Content

IJAHM Menu

Download

Crossref - DOI

DOI : 10.47191/ijahm

Impact Factor 2024: 8.003

2023: 7.734

2022: 6.704

2021: 6.643

2019: 5.692

2018: 5.485

2017: 4.965

2016: 4.415 

Facebook

Who's Online

We have 342 guests and no members online

index

ind.pngkindex.jpglogo_2.pngnewj.pngtop_up.jpguindex.jpgule.jpg
 Copyright © 2024 IJAHM  Rights Reserved.