¹Dr. Narendra Bhatt, ²Dr. Manasi Deshpande

 DOI : http://dx.doi.org/10.47191/ijahm/v12i2.03

¹ Consultant Ayurveda – Research & Industry, CRIA Consultants Pvt. Ltd. 15, Bachubai Building, J.Bhatankar Marg, Parel, Mumbai 400 012,

 ² Professor and Head, Department of DravyagunaVigynan, Bharati Vidyapeeth [Deemed to be University] , College of Ayurved, Pune, 411043

 *Corresponding author: Dr. Manasi  Deshpande

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ABSTRACT:

Progression of chronic liver disease to hepatocellular carcinoma is not uncommon in India. Approximately 22,000 new cases of primary liver cancer are reported annually in the country. HCC is very complex and unique when compared with other cancer types. Treatment such as surgical resection, ablation, and chemo-embolization is useful only to selected patients. Over all very low (4%) survival rate of HCC underlines the limitations in treatment options and marks it as cause of major health burden. At present, liver transplantation remains the only curative option for the patients of cirrhosis and end stage liver diseases.

The etiology and pathology of HCC is not clearly defined in detail in the Indian system of medicines. But tumors are discussed under the names various ASU terminology to designate basic common neoplasms, which can appear in any tissue or organ of the body. Both allopathic and ASU systems generally refer to neoplasms as the uncoordinated abnormal cell growth found within particular organs or body tissues.

The Indian systems of medicine are the oldest traditional medicinal systems offering treatments for chronic liver diseases and cirrhosis for centuries. A large number of single and compound drug formulations are documented to have benefit over chronic liver conditions as hepatic tonic. The therapeutic benefits offered by various ASU formulations in treatment of chronic liver diseases have however not much explored in treatment of HCC. Experiments on animals and cell cultures have shown that some potential plants can alleviate and prevent pathological changes in the liver.

The present paper is an attempt to list the plants with hepatoprotective and related beneficial effects which are used in Indian system of medicines. An attempt has been made to provide details on validation of certain potential plant drugs for anticancer and anti-metastatic properties against hepatocellular carcinoma.

Key words- Liver disorders, HCC, Hepatoprotective, Phytochemicals,  Ayurveda, Indian Medicinal plants

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