Malpani Arati^1*, Shetgar Chanbas², Avute Ramesh³, Jadhav Preeti J⁴

^1,3,4Department of pharmacology, HKES’s MTRIPS, M.R.Marg, Sedam road, Kalaburagi, Karnataka, India. 585105

²Department of pharmacology, SSPM’s Shramjivi College of Pharmacy, Sainagar, Umerga, Dist. Osmanabad, Maharashtra, India. 413606

DOI : http://dx.doi.org/10.47191/ijahm/v14i5.10

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ABSTRACT: Pharmacological properties of ginger include anticancer, antiulcer, spermicidal, antidiabetic, antioxidant, antibacterial, anti-neuroinflammatory, and anti-vomiting effects when used in chemotherapy. In this work, female Wistar albino rats were used as test subjects to examine the antifertility effects of an ethanolic and aqueous extract of Zingiber officinale rhizomes. Anti-fertility activity of both the extracts were carried out in female Wistar rats at the both doses (200mg/kg & 400mg/kg) by evaluating number of implants on day 10, number of pups born and level of hormones (LH, FSH).To know the exact mechanism of action uterotropic assay was carried out in which, the estrogenic effects of EEZO were further observed by administering it to the female immature Wistar albino rats  and parameters evaluated were vaginal cornification, uterine weight, body weight, histopathology of uterus and biochemical parameter(Estrogen). Alkaloids, flavonoids, steroids, terpenoids, and resins are among the phyto-constituents found in the two extracts, according to phytochemical research. The number of implants (P<0.001) and pups born (P<0.0001) significantly decreases as a result of the anti-fertility activity. The greatest 50% reduction in pregnancies was seen in rats treated with EEZO.The most powerful extract, EEZO, was investigated for its oestrogenic effects; results included increased body and uterine weight, vaginal cornification, and uterine proliferation. Hormonal and biochemical tests confirmed the previous findings demonstrating the oestrogenic potential of EEZO, which may be connected to the phytoestrogen (quercetin) content of the plant.It was observed that Zingiber officinale extracts had a strong oestrogenic and abortifacient effect. This could be because the extract contains zingiberene, a sesquiterpene called phytoestrogen (quercetin).

KEYWORDS:  Anti-fertility; Zingiber officinale; abortifacient; Anti-Implantation; Estrogenic agent

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