¹Assistant Professor, Department of Community Medicine,RUMCHRC,Jaipur Rajasthan

²Lecturer, Department of Community Medicine,NIUM,Bangaluru,Karnataka

Abstract :

Objectives: To assess the efficacy of Aabresham (Bombyx mori) for the prevention of atherosclerosis.

Methods: Randomized single blind standard control risk factor trial was conducted in National Institute of Unani Medicine Hospital, Bangalore from March 2015 to March 2016.

Fifty patients with risks of atherosclerosis were selected and randomly assigned into two groups 30 in test group and 20 in control group. Test group was treated with the decoction of Aabresham (Bombyx mori), six grams in the morning empty stomach for two months and control group was treated with Atorvastatin, ten mg, in the evening for the same duration. The response was evaluated by the assessing the subjective and objective parameters. The result was analyzed statistically by using Fisher Exact test, Chi-Square test and Student‘t’ test (Unpaired & Paired).

Results: Test group showed significant reduction in breathlessness, palpitation, headache, blood pressure, serum cholesterol, Low density lipoprotein (LDL) & MDA (Malonedialdehyde)

concentration (p<0.01) but chest pain, serum triglyceride, haematocrit and HDL(High density lipoprotein) values were found statistically insignificant in both groups. Overall, improvement was observed in test group except blood urea.

Conclusion: Aabresham(Bombyx mori shown to have an astounding potential in the prevention of atherosclerosis. It’s anti-oxidant, anti inflammatory, platelet stabilizing and anti- arrhythmic effect plays an unparallel role in the inhibition of development & progression of atherosclerosis. Integration with regimental therapies and dietary modification will potentiate its efficacy.

Keywords:  Atherosclerosis, Marz-e-majari, Sudda, Aabresham

 REFERENCES

1.    W. Slijkhuis, W. Mali, Y. Appelman. A historical perspective towards a non-invasive treatment for patients with atherosclerosis. Netherlands Heart Journal.                   2009 April; 17(4): p. 140-141.

2.      Anonymous. Atherosclerosis.National Heart,Lung and Blood Institute. [Online]; 2016 Jan. Available from: http://www.nhlbi.nih.gov/health-topics/atherosclerosis/

3.      Shanthi Mendis, Pekka Puska, Bo Norrving. Global Atlas on cardiovascular disease prevention and control. World Health Organization. Geneva; 2011: p. 1-153.

4.      World Health Organization. Cardiovascular diseases. [Online] Geneva 2011. Available from: http://sancd.org/uploads/pdf/factsheet_CHD.

5.      Jane A. Leopold, Joseph Loscalzo. Oxidative Risk for Atherothrombotic Cardiovascular Disease. Free Radic Biol Med. 2009 December 15; 12(47): p. 1673-1706.

6.      Rushd I. Kitabul Kulliyat. New Delhi: CCRUM; 1989: p. 87-90.

7.      Ghani N. Khazainul Advia. New Delhi: Idara Kitabul Shifa; 2010: p. 749-750.

8.      Anonymous. High blood cholesterol.ATP III Guidelines at a glance quick desk reference. National heart,lung and blood institute; 2001.

9.      Gururaj M. Kuppuswamy’s Socio-Economic Status Scale – A Revision of Income Parameter For 2014. International Journal of Recent Trends in Science And Technology. 2014; 11(1): p. 1-2.

10.  The Criteria Committee for the New York Heart Association. Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. 9th ed: Little Brown and Company; 1994.

11.  Michael S, Peter J I. congestive heart failure (Furosemide): Diagnosis,Pathophysiology, Therapy and implementations of Respiratory care. Respiratory Care. 2006 April; 51(4): p. 403-410.

12.  J. C. Witteman, D. E. Grobbee, F. J. Kok, A. Hofman, and H. A. Valkenburg.Increased risk of atherosclerosis in women after the menopause. BMJ. 1989 March; 298(6674): p.642–644.

13.  Manish Verma, Poonam Verma, Shabnam Parveen, Karuna Dubey. Comparative Study of Lipid Profile Levels in Vegetarian and Non-Vegetarian Person. International Journal of Life-Sciences Scientific Research. 2015 Nov; 1( 2): p: 89-93

14.George Howard,etal.Cigarette Smoking and Progression ofAtherosclerosis.The Atherosclerosis Risk in Communities (ARIC) Study. JAMA. 1998 ; 279(2) : p.119­124.

15.  Panniyammakal Jeemon, K.S. Reddy. Social determinants of cardiovascular disease outcomes in Indians. Indian J Med Res. 2010 Nov; 132(5): p. 617–622.

16.  Pandey AK, Pandey S, Blaha MJ, Agatston A, Feldman T, Ozner M ,et al. Family history of coronary heart disease and the incidence and progression of coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA). Elsevier. 2013 March; 232 (2014): p. 369-376.

17. Yu Chen, Wade K Copeland, Rajesh Vedanthan, Eric Grant, Jung Eun Lee,Dongfeng Gu, etal.Association between body mass index andcardiovascular disease mortality in east Asiansand south Asians: pooled analysis of prospectivedata from the Asia Cohort Consortium. BMJ . 2013 Oct; 347: p. 1-25.

18.World Health Organization. Physical inactivity a leading cause of disease and disability, warns.WHO.Geneva.[Online];2016.Availablefrom:http://www.who.int/mediacentre/news/release23/en/

19.  Georgia V, Dimitris T, Christodoulos S. The Role of Oxidative Stress in Atherosclerosis. Hellenic J Cardiol. 2009;(50): p. 402-409.

20.  David Weiner, William E.Mitch, Jeff M.Sands. Clinical journal of the American society of nephrology. [Online]; 2014. Available from: http://cjasn.asnjournals.org/content/early/

21.  Maggie B C. Omega­3 Fatty Acids. American family physicians. 2014 July 1; 1(70): p. 133-144.

22.  Islam M. An update on the cadiovascular effects of qercetin, a plant flavonoid. Current nutrition and food science. 2014;(10): p. 36-48.

23.  Gross M. Flavonoids and Cardiovascular Disease. Pharmaceutical Biology. 2004; 42: p. 21-35.

24.  M. Mondal, K.Trivedy,S.Nirmal K. The silk proteins, sericin and fibroin in silkworm, Bombyx mori Linn. - a review. Caspian Journal of Environmental Sciences. 2007; 5(2): p. 63-76.

25.  Kushal Sen MB. Studies on Indian silk.I.Macrocharacterization and analysis of amino acid composition. Journal of applied polymer science. 2004 Feb 18; 92(2): p. 1080-1097.

26.  Guiseppe cirillo Fl. Anti oxidant polymer synthesis,properties and application: Wiley; 2012: p. 12-37.

27.  Mark F Mc Carty,  James J Di Nicolantonio. The cardiometabolic benefits of glyceine:Is glycine an antidote to dietary fructose. Open Heart. 2014;1(1): p.1-9. 

28.  Mark F Mc Carty,  James J Di Nicolantonio. β-Alanine and orotate as supplements for cardiac protection.Open Heart. 2014;1(1): p.1-9.

29.  Aluko Chibuike, C. Udenigwe, Rotimi E. Chemometric Analysis of the Amino Acid Requirements of Antioxidant Food Protein Hydrolysates. International Journal of Molecular Sciences. 2011; 12: p. 3148-3161.

30.  Oda H. Functions of Sulfur-Containing Amino Acids in Lipid Metabolism. The journal of nutrition. 2006: p. 1666-1669.

31.  David Gersten.Amino Acids and Heart Health. The Life Connection. [Online]; 2013. Available from: http://lifeconnectionmagazine.com/amino-acids-and-heart-health-by-david-gersten-med/    

32.  Hursen M, Regan MC, Krik SJ. Metabolic effects of arginine in a healthy elderly population. Journal of parenteral and enteral nutrition. 1995; 19: p. 227-230.

33.  K, Sumizu. Oxidation of hypotaurine in rat liver. Biochim. Biophys. Acta. 1962; 63: p. 210

34.  Chapman RA, Suleinan MS, Earm YE. Taurine and the heart. Cardiovascular research.1993; 27(3): p. 358-363.

35.  Ibn Sina. Al Qanoon  (Urdu translation by Kantoori GH). New Delhi:Idara Kitabul Shifa; 2007: p. 349,758-766.

36.  David Gersten.Amino Acids and Heart Health. The Life Connection. [Online]; 2013. Available from: http://lifeconnectionmagazine.com/amino-acids-and-heart-health-by-david-gersten-med/    

37.  Hursen M, Regan MC, Krik SJ. Metabolic effects of arginine in a healthy elderly population. Journal of parenteral and enteral nutrition. 1995; 19: p. 227-230.

38.  K, Sumizu. Oxidation of hypotaurine in rat liver. Biochim. Biophys. Acta. 1962; 63: p. 210

39.  Chapman RA, Suleinan MS, Earm YE. Taurine and the heart. Cardiovascular research.1993; 27(3): p. 358-363.

40.  Ibn Sina. Al Qanoon  (Urdu translation by Kantoori GH). New Delhi:Idara Kitabul Shifa; 2007: p. 349,758-766.

41.  Wikipedia.Atorvastatin.[Online];2014 Feb.Available from: http://Atorvastatin%20­%20Wikipedia,%20the%20free%20encyclopedia.html