Therapeutic Potentials of Bioactive Compounds of Azadiracta Indica ( Neem) to Treat Ailments of Humanbeing

Associate Professor of Biochemistry P.V.K.N.Govt.College, Chittoor Andhra Pradesh, India

ABSTRACT

Azadiracta indica (Neem) native of India has uncountable medicinal properties of variousbioactive compounds which are present in the roots to seeds of this plant.Biologically active compounds namely Azadirachtin, meliacin, , Meliantriol ,Nimbin, Nimbidin, Salannin, Salannol vilasinin,are isolated from different parts of Neem plant .Biologically more active compound is azadirachtin, a tetranotriterpenoid is isolated from the seeds of Neem which is actually a mixture of seven isomeric compounds named as azadirachtin A-G and azadirachtin E is the most effective one. Two bioactive compounds azadirachtin M and azadirachtin N collected from seed kernels of Azadirachta indica,these two compounds hasa major role in medicinal activities.The bioactive compound “Azadiachtin” has antimalarial, antigingivitis and antiplaque properties and also has antibacterial action by destroying the bacterial cells.The bioactive compound Nimbidin has anti- inflammatory antipyretic , antiarthritic , hypoglycemic , anti- gastric ulcer, antibacterial and antifungalproperties.Nimbin exhibits spermicidal function. The neem oil was extracted from neem kernels. This oil used in soap industry and by pharmaceutical industries and contain many active ingredients which are called triterpene or limonoids .Neem oil showed good antiseptic properties. It is applied in the treatment of skin complaints as furuncles and eczema.Therapeutical potentials of neem is due to the presence of various Bioactive compounds in roots to seeds of its body.

Key Words: (1). Azadiracta indica (2). Bioactive compounds (3). Azadiractin,(4). Nimbin, (5). Nimbidin etc., (6). Antimalarial, anti inflammatory and antiarthritic etc

REFERENCES

1. Ara I, siddiqui B S, faizi S, and sidddiqui S. structurally novel diterpenoid constituents from the stem bark of Azadirachta indica(melieceae). J. chem soc perkin trans 1989; 2,343-345.

2. Bannerman RH. Traditional medicine in modern health care. World Health Forum 1982; 3(1): 8–13.

3. Bhowmik D, Yadav J, Tripathi K, Kumar KS. Herbal remedies of Azadirachta indica and its medicinal application. J. Chem Pharm Res 2010;2(1):62-72.

4. Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. Biological activities and medicinal properties of neem (Azadirachta indica). Curr Sci 2002;82(11):1336-45.

5. Sharma V N, Saksena K P, „Sodium nimbidinate-in vitro study of its spermicidal action .Indian journal [34] Rachanakij S, Thebtarananth Y, Yenjal C H and Yuthavong Y, nimbolide a constitute of Azadirachtaindicainhibits Plasmodium falciparum in culture southeast Asian j trop med public health 1985, 16, 6ORDERED REFERENES FINAL TO PULISHORDERED FINAL REFERENCE

6. Botelho MA, Santos RA, Martins JG, Carvalho CO, Paz MC, Azenha C et al. Efficacy of a mouth rinse based on leaves of the neem tree (Azadirachtaindica) in the treatment of patients with chronic gingivitis: A double blind, randomized, controlled trial. J Med Plant Res 2008;2(11):341–346.

7. Brahmachari G. Neen-An omnipotentplant: a retrospection.Chembiochem 2004;5(4):408-21.

8. Butterworth JH, Morgan E. Isolation of a substance that suppresses feeding in locusts. Chem Commun 1968 ; (1):23-4.

9. Chatterjee A, Saluja M, Singh N, Kandwal A. To evaluate the antigingivitis and antipalque effect of an Azadirachta indica (neem) mouthrinse on plaque induced gingivitis: A double-blind, randomized, controlled trial. J Indian Soc Periodontol 2011;15 (4):398-401.Chem draw Ultra12.0

10. Debashri M, Tamal MA. Review on efficacy of Azadirachta indica A. Juss based biopesticides An Indian perspective.Res J Recent Sci 2012;1(3):94-9.

11. Djenontin Tindo S, Amusant N, Dangou J, Wotto D, Avlessi F, DahouénonAhoussi E et al. Screening of Repellent, Termiticidal and Preventive activities on Wood, of Azadirachta indica and Carapa procera (Meliaceae) seeds oils. ISCA J Biological Sci 2012;1(3):25-9.

12. Forster P, Moser G. Status report on global neem usage: Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ). Eschborn Germany 2000; p 122.

13. Girish K, Shankara Bhat S. Neem–a green treasure. Electron J Biotechnol 2008;4(3):201-111.

14. Habluetzel A, Lucantoni L, Esposito F. Azadirachta indica as a public health tool for the control of malaria & other vector-borne diseases. Indian J Med Res 2009;130(2):112-4.

15. Hashmat I, Azad H, Ahmed A. Neem (Azadirachta indica A. Juss)-A nature’s drugstore: an overview Int Res J Biol Sci 2012;1(6):76-9.

16. Hedge N G. Neem and small farmers constraints at grass root level. Indian Forester 1995;121 (11):1040-8.

17. Kabeh J D, and Jalingo M G D S S .Exploiting Neem( Azadiracta indca) Resource for Improving the Quality of Life in Taraba State , Nigeria. International Journal ofAgriculture and Biology 2007; 9 (3) :530-532.

18. Kakai T, Koha J P. anti-inflammatory polysaccharides from Melia Azadirachta . chem Abstr 1984;100,913-50.

19. Khare CP. Indian medicinal plants: an illustrated dictionary. Springer, 2007.

20. Klocke J. Plant compounds as source and models of insect-control agents research Eamp.Editor, Academic Press, London, 1989, 103-44.

21. Lale N E. Bio-activity and limitation against wide spread use of neem products for the management of insect pests. Niger J Appl Biol 2002;3 (1):115-24.

22. Ley S V. Development of methods suitable for natural product synthesis: The azadirachtin story. Pure Appl Chem 2005; 77(7):1115-30.

23. Luo X, Ma Y, Wu S, Wu D. Two novel azadirachtin derivatives from Azadirachta indica. J Nat Prod 1999;62(7):1022-4.

24. Morgan ED. Azadirachtin, a scientific gold mine. Bioorg Med Chem 2009;17(12): 4096-105. 10

25. Murthy S P, and Sirsi M 1958. Pharmacological studies on melia Azadirachta indica. Indian journal of physicology and pharmacology 1958; 2, 387-396 .

26. Ngure RM, Ongeri B, Karori SM, Wachira W, Maathai RG, Kibugi J et al. Anti-trypanosomal effects of Azadiracta indica (neem) extract on Trypanosoma brucei rhodesiense-infected mice. Eastern J Med 2013;14(1):2-9.

27. Pandey IP, Ahmed SF, Chhimwal S, Pandey S. Chemical Composition and Wound healing activity of Volatile oil of Leaves of Azadirachta indica A. juss. Adv Pure Appl Chem 2012;1(3):62-6.

28. Pankaj S, Lokeshwar T, Mukesh B, Vishnu B. Review on neem (Azadirachta indica):Thousand problems one solution. IRJP 2011;2(12):97-102.

29. Pillai N R and Santhakumari G. antiarthritic and anti- inflammatory actions of nimbidin planta medics 1981;43,59-63.

30. Puri HS. Azadirachta indica. Amsterdam. Harwood Academic Publishers; 1999. Neem: The divine tree; pp. 1–3.

31. Sanjay k Sharma, Anjali Peter and Ime Bassey Obot. Potential of Azadiracta indica as a Green corrosion inhibitor against mild steel, aluminium and tin: a review. Journal of Analytical science and technology 2015; 6: 26.

32. Sathish Kumar A S, Kotte Subhash Chandra Bose, Pavan Kumar K V T S, Shri Ram Ragahvan and Murali P. Terpenoids and its commercial Utility from Neem The Nature’ s Own Pharmacy. Asian journal of Chemistry 2014; 26(16): 4940-4948.

33. Schmutterer H. Properties and potential of natural pesticides from the neem tree, Azadirachta indica. Annu Rev Entomol 1990 ; 35:271-97.

34. Shradha M.Patel, Kalyan c, Nagulapalli Venkata, Piyali Bhattacharyya, Gautam Sthi and Anupam Bishayee. Potential of neem( Azadiracta indica L.) for prevention and treatment of Oncologic diseases. Seminars in Cancer Biology 2016 VOL.40-41, PAGES 100-115.

35. ( 35). Subbarayappa BV. Siddha medicine: an overview. Lancet 1997;350(9094):1841–1844. [PubMed

36. P. Sudhir Kumar, Debasis Mishra, Goutam Ghosh and Chandra S Panda. Biological action and medicinal properties of various constituent of Azadirachta indica (Meliaceae) an Overview. Annals of Biological Research 2010;1 (3) :24-34.

37. Tiwari R, Verma AK, Chakraborty S, Dhama K, Singh SV. Neem (Azadirachta indica) and its potential for safeguarding health of animals and humans: A review. J Biol Sci 2014;14(2):110-23.

38. Turner CJ, Tempesta MS, Taylor RB, Zagorski MG, Termini JS, Schroeder DR et al. An NMR spectroscopic study of azadirachtin and its trimethyl ether. Tetrahedron 1987;43(12):2789-803.

39. Uko OJ, Kamalu TN. The neem tree-uses and potentials. Niger J Exp Appl Biol 2001; 2 (2):223-9. United Nations Environment Programme Neem. 2012.

40. Veitch GE, Pinto A, Boyer A, Beckmann E, Anderson JC, Ley SV. Synthesis of natural products from the Indian neem tree Azadirachta indica. Org Lett 2008;10(4):569-72.

41. Verkerk R H, Wright DJ. Biological activity of neem seed kernel extract and synthetic azadirachtin against larvae of Plutella xylostellal. Pestic Sci 1993;37 (1):83-91

42. Vietmeyer ND. Neem: a tree for solving global problems. Report of an adhoc panel of the Board on Science and Technology for International Development.1992.

43. Warra A A. Medicinal and cosmetic potential of neem (Azadiracta indica) seed oil: A review. Res Rev J Med Chem 2012;1 (1):5-8.